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Full Description
Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondriain host-pathogen interactions.
Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.
Contents
Chapter 1. Mitochondrial Metabolism in Cancer. A Tangled Topic. Which Role for Proteomics? (Roberto Scatena).- Chapter 2. Mitochondrial Proteins in the Development of Parkinson's Disease (Mauro Fasano and Tiziana Alberio).- Chapter 3. Role of Mitochondria in Host-Pathogen Interaction (Alessio Soggiu).- Chapter 4. Mitochondria Lysine Acetylation and Phenotypic Control (Federica Ciregia).- Chapter 5. Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis (Viviana Greco).- Chapter 6. A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes (Zhuoran Wu).- Chapter 7. Targeted Proteomics to Study Mitochondrial Biology (Rainer Bischoff and Karin Wolters).- Chapter 8. Recent Advances in Targeting Human Mitochondrial AAA+ Proteases to Develop Novel Cancer Therapeutics (Walid Houry).- Chapter 9. Investigating the Role of Mitochondria in Type 2 Diabetes - Lessons from Lipidomics and Proteomics Studies of Skeletal Muscle and Liver (Albert Sickmann).- Chapter 10. Quantification of Mitochondrial Network Characteristics in Health and Disease (Jeff Stuart).- Chapter 11. Cysteine Switches and the Regulation of Mitochondrial Bioenergetics and ROS Production (Ryan Mailloux).- Chapter 12. Advances Towards Therapeutic Approaches for mtDNA Disease (Timothy Shutt).- Chapter 13. Mitochondrial Genetics (Vanessa Goncalves).- Chapter 14. Heteroplasmy Shifting as Therapy for Mitochondrial Disorders (Neal Sondheimer).- Chapter 15. Mitochondrial Function and Dysfunction in Alzheimer's Disease (Benedict Albensi).- Chapter 16. Application of CRISPR-Cas9 Screening Technologies to Study Mitochondrial Biology in Healthy and Disease States (Steven Chan).
