Total Synthesis of Natural Products with Antimicrobial Activity (Springer Theses)

Giltrap, Andrew

Springer Verlag, Singapore（2019/02発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 268 p.
• 言語 ENG
• 商品コード 9789811342455
• DDC分類 612.015

Full Description

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

Contents

Introduction.- Total Synthesis of Teixobactin.- Synthesis of Deshydroxy Skyllamycins A-C.- Total Synthesis of Skyllamycins A-C.- Experimental.