Full Description
This new edition is a comprehensive guide to recurrent pregnancy loss for practising gynaecologists.
Divided into ten sections, the book begins with a brief overview of the topic, followed by discussion on the different causes of pregnancy loss - genetic, endometrial, systemic, anatomical and infections. The next sections discuss management options, the role of ultrasound, and failed pregnancy.
The third edition has been fully revised and expanded to bring clinicians fully up to date with the latest advances in the field.
Newer treatment options are covered in depth and the latest diagnostic recommendations from the RCOG (UK) as well as the ACOG (US) are included.
Authored by a team of internationally recognised experts, the text is enhanced by clinical photographs and diagrams, and features a comprehensive appendix section for further reference.
Key points
Fully revised, third edition presenting latest knowledge in recurrent pregnancy loss
Covers newer treatment options and latest diagnostic recommendations from RCOG and ACOG
Authored by internationally recognised team of experts
Previous edition (9788184480061) published in 2007
Contents
Section 1: Introduction
Overview & Terminology Clarified
Cytokines and The Success/Failure of Pregnancy
Section 2: Genetic Causes
Overview of Genetic Causes
Single Gene Disorders & Telomeric Deletions
Preimplantation Genetic Testing (PGD/PGS) - An Evidence Based Update
Male Factors
Sperm DNA Fragmentation Index
Section 3: Endometrial Causes
Endometrial Factors
Endometrial Receptivity Array - ERA
Section 4: Systemic Causes
APL Syndrome
Autoimmune Disorders
Hyperhomocysteinemia
Inherited Thrombophilia
Endocrinal Causes
PCOS
Poor Oocyte Quality - Ovarian Aging
Section 5: Anatomical Causes
Anatomical Factors
Endometriosis
Adenomyosis
Intrauterine Adhesions
Cervical Cerclage - Benefits & Controversies
Role of Endoscopy
Section 6: Infections
Latent Genital TB & Subclinical Endometritis
Treatment of Female Genital Tuberculosis
Sexually Transmitted Diseases: Chlamydia, Syphilis & HIV
Bacterial Vaginosis
Natural Killer Cells
Section 7: Miscellaneous
Obesity
Late Pregnancy Loss
Immune & Non-immune Fetal Hydrops
Recurrent Molar Pregnancies
Recurrent Implantation Failures & Biochemical Pregnancies
Psychoneuroimmunology - Role of Stress
Section 8: Management Options
Role of Progesterone
Role of Dydrogesterone
Role of GCSF
Role of IVF
Role of Lymphocyte Immunotherapy
Oxidative Stress & Role of Antioxidants & Micronutrients
Role of Tender Loving Care
Management of Patients with Multiple Treatment Failures Howard Carp
Section 9: Role of Ultrasound
Scanning the Non-pregnant Patient
Early Pregnancy and Reassurance Scans
Section 10: Failed Pregnancy
Role of Embryoscopy, Fetal Karyotyping & Placental Biopsy
Surgical Versus Medical Evacuation
Grief Counselling in Recurrent Pregnancy Loss
Medicolegal Implications
Appendices
Appendix 1. Role of DHEAS
Appendix 2. Role of Uterine Stem Cells
Appendix 3. Role of Thromboelastography
Appendix 4. Diagnostic Tests for Autoimmunity and Alloimmunity
Appendix 5. Algorithm on Clinical Management
