Full Description
Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
Contents
P-glycoprotein structure and evolutionary homologies.- Molecular analysis of the multidrug transporter, P-glycoprotein.- Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transport.- Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs.- A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression.- Intracellular distribution of anthracyclines in drug resistant cells.- Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance.- Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP.- Topoisomerase I inhibitors and drug resistance.- Mechanisms of resistance to alkylating agents.- Drug resistance and DNA repair in leukaemia.- Nucleotide excision repair and anti-cancer chemotherapy.- Protein kinases and multidrug resistance.- New insights into the kinetic resistance to anticancer agents.- The extended-MDR phenotype.- Role of oxygenation and vascularization in drug resistance.- Transcriptional regulation of MDR genes.- Cytokine-mediated reversal of multidrug rsistance.- The role of oncogene in drug resistance.- Apoptosis resistance in tumor cells.- Regulation of caspase activation in apoptosis: implications for transformation and drug resistance.- Regulation of keratin and integrin gene expression in cancer and drug resistance.
