Full Description
Dr. Jurg Ott is a pioneer in the field of statistical genetic analysis and authored the first publicly accessible computer program on human linkage analysis. His work led to some of the first methods for computer simulation in family pedigrees and provided the statistical framework underlying newer approaches to haplotype relative risk methods that have become important tools in the search for disease-marker associations. This special issue of 'Human Heredity' is inspired by the seminar work performed by Dr. Jürg Ott over his amazing career. There are papers ranging from review work on linkage analysis performed by Dr. Jurg Ott early in his career, to new statistical methods for next-generation sequencing utilizing the SumStat approach method for multilocus inheritance, which was developed within the last several years. Anyone interested in statistical genetics, genetic epidemiology, novel methods, and state of the art technologies for analyzing the next wave of genetic data will benefit from reading this issue.
Contents
Introduction - Analysis of Human Genetic Data: A Celebratory Issue of Human Heredity Honoring Dr. Jurg Ott: Devoto, M.; Gordon, D.; The Structure of Genetic Linkage Data: From LIPED to 1M SNPs: Thompson, E.; Attempted Replication of 50 Reported Asthma Risk Genes Identifies a SNP in RAD50 as Associated with Childhood Atopic Asthma: Murk, W.; Walsh, K.; Hsu, L.-I; Zhao, L.; Bracken, M.B.; DeWan, A.T.; Novel Autosomal Recessive Nonsyndromic Hearing Impairment Locus DFNB90 Maps to 7p22.1-p15.3: Ali, G.; Lee, K.; Andrade, P.B.; Basit, S.; Santos-Cortez, R.L.P.; Chen, L.; Jelani, M.; Ansar, M.; Ahmad, W.; Leal, S.M.; A New Expectation-Maximization Statistical Test for Case-Control Association Studies Considering Rare Variants Obtained by High-Throughput Sequencing: Gordon, D.; Finch, S.J.; De La Vega, F.; Coordinated Conditional Simulation with SLINK and SUP of Many Markers Linked or Associated to a Trait in Large Pedigrees: Schaffer, A.A.; Lemire, M.; Ott, J.; Lathrop, G.M.; Weeks, D.E; Genome-Wide Linkage Analysis to Identify Genetic Modifiers of ALK Mutation Penetrance in Familial Neuroblastoma: Devoto, M.; Specchia, C.; Laudenslager, M.; Longo, L.; Hakonarson, H.; Maris, J.; Mosse, Y.; Author Index; Subject Index.
