Full Description
The second edition of Immune 'Response and the Eye' highlights recent insights into the 'dangerous compromise' between the immune system and the eye, which protects the eye against pathogens while limiting inflammation and immune-mediated injury to ocular tissues with little or no regenerative potential. It discusses the broad spectrum of physiological, immunological, anatomical, and biochemical adaptations that conspire to closely regulate the tone and tenor of immune responses in the eye. This volume further describes immune-mediated diseases that occur when the compromise between the immune system and the eye is breached. This breakdown in immune privilege threatens the vision of millions each year. Finally, recent advances in ocular immunology are presented, which offer potential therapeutic applications in corneal and retinal transplantation and in the management of blinding autoimmune diseases of the eye. Eye researchers, ophthalmologists and immunologists will appreciate the state-of-the-art and authoritative information presented in 'Immune Response and the Eye'.
Contents
Introduction; Rationale for Immune Response and the Eye: Niederkorn, J.Y.; Kaplan, H.J.; Anatomy and Function of the Eye: Kaplan, H.J.; Regional Immunity and Immune Privilege: Kaplan, H.J.; Niederkorn, J.Y.; Physiology of Immune Response and the Eye; The Induction of Anterior Chamber-Associated Immune Deviation: Niederkorn, J.Y.; Anatomy and Immunology of the Ocular Surface: Knop, E.; Knop, N.; Immune Privilege and Angiogenic Privilege of the Cornea: Cursiefen, C.; Corneal Antigen-Presenting Cells: Hamrah, P.; Dana, M.R.; Ocular Immunosuppressive Microenvironment: Taylor, A.W.; Immunosuppressive Properties of the Pigmented Epithelial Cells and the Subretinal Space: Zamiri, P.; Sugita, S.; Streilein, J.W.; Major Histocompatibility Complex Molecules on Parenchymal Cells of the Target Organ Protect against Autoimmune Disease: Shao, H.; Kaplan, H.J.; Sun, D.; Complement, Innate Immunity and Ocular Disease: Sohn, J.-H.; Bora, P.S.; Jha, P.; Tezel, T.H.; Kaplan, H.J.; Bora, N.S.; Cross Talk among Cells Promoting Anterior Chamber-Associated Immune Deviation: Stein-Streilein, J.; Watte, C.; Regulatory T Cells and the Eye: Niederkorn, J.Y.; The Role of Fas Ligand and TNF-Related Apoptosis-Inducing Ligand (TRAIL) in the Ocular Immune Response: Ferguson, T.A.; Griffith, T.S.; Immune-Mediated Ocular Diseases; Impact of Inflammation on Ocular Immune Privilege: Mo, J.-S.; Wang, W.; Kaplan, H.J.; Allergy and Contact Lenses: Siddique, M.; Manzouri, B.; Flynn, T.H.; Ono, S.J.; Dry Eye Syndromes: Barabino, S.; Dana, M.R.; Bacterial Infections of the Cornea (Pseudomonas aeruginosa): Hazlett, L.D.; Cicatrizing and Autoimmune Diseases: Rashid, S.; Dana, M.R.; How Herpes Simples Virus Type 1 Rescinds Corneal Privilege: Lepisto, A.J.; Frank, G.M.; Hendricks, R.L.; Intraocular Diseases - Anterior Uveitis: Bora, N.S.; Kaplan, H.J.; Glaucoma: Tezel, G.; Wax, M.B.; Intermediate and Posterior Uveitis: Forrester, J.V.; Acute Retinal Necrosis: Kezuka, T.; Atherton, S.S.; Onchocerca volvulus, Wolbachia and River Blindness: Pearlman, E.; Gillette-Ferguson, I.; Role of Bacterial Host Factors in Infectious Endophthalmitis: Gregory, M.; Gilmore, M.S.; Callegan, M.C.; Influence of Immune Surveillance and Immune Privilege on Formation of Intraocular Tumors: Chen, P.W.; Ksander, B.R.; Treatment of Immune-Mediated Ocular Diseases; Immunogenicity and Immune Privilege of Corneal Allografts: Hori, J.; Niederkorn, J.Y.; Retinal Transplantation: Ng, T.F.; Klassen, H.J.; Hori, J.; Young, M.J.; Therapies Based on Principles of Ocular Immune Privilege: Zhang-Hoover, J.; Stein-Streilein, J.; Author and Subject Index.
