基本説明
Reprint of: Cytogenetic and Genome Research 2006, Vol. 113, No. 1-4.
Full Description
Genomic imprinting, a parent-of-origin-specific epigenetic modification of the genome, is observed in placental mammals and some plants (angiosperms). Since its discovery in the early 1980s, this intriguing phenomenon has been intensively investigated and has spawned an exciting new research area. Imprinting is relevant to a variety of biological events such as embryogenesis, growth and behavior, and its disruption can lead to congenital malformation syndromes and cancers. Furthermore, imprinting has been serving as an excellent model system to study epigenetic mechanisms of gene regulation and helping us to understand how gene clusters and genome domains are regulated. This special issue provides an overview of the current knowledge of genomic imprinting. Including both excellent reviews and original research articles by outstanding researchers in the field, many of which were participants of the genomic imprinting workshops in Montpellier (September 2004) and Oxford (April 2005), it represents the forefront of imprinting research.
Contents
Preface; Biological Significance and Evolution; The continuing quest to comprehend genomic imprinting: Miyoshi, N.; Barton, S.C.; Kaneda, M.; Hajkova, P.; Surani, M.A.; Imprinting today: end of the beginning or beginning of the end?: Solter, D.; Interactions between imprinting effects: summary and review: Cattanach, B.M.; Beechey, C.V.; Peters, J.; Complementation hypothesis: the necessity of a monoallelic gene expression mechanism in mammalian development: Kaneko-Ishino, T.; Kohda, T.; Ono, R.; Ishino, F.; Genomic imprinting is a barrier to parthenogenesis in mammals: Kono, T.; Origins of extreme sexual dimorphism in genomic imprinting: Bourc'his, D.; Bestor, T.H.; Regulatory Mechanisms; How imprinting centres work: Lewis, A.; Reik, W.; Genomic imprinting in the placenta: Wagschal, A.; Feil, R.; Small non-coding RNAs and genomic imprinting: Royo, H.; Bortolin, M.-L.; Seitz, H.; Cavaille, J.; Repetitive elements in imprinted genes: Walter, J.; Hutter, B.; Khare, T.; Paulsen, M.; The role of DMDs in the maintenance of epigenetic states: Paoloni-Giacobino, A.; Chaillet, J.R.; Regulation of imprinted DNA methylation: Holmes, R.; Soloway, P.D.; Imprinted Genes/Domains; Genome-wide survey of imprinted genes: Maeda, N.; Hayashizaki, Y.; Establishment and maintenance of H19 imprinting in the germline and preimplantation embryo: Reese, K.J.; Bartolomei, M.S.; Lessons from comparative analysis of species-specific imprinted genes: Okamura, K.; Ito, T.; The imprinted mouse Igf2r/Air cluster - a model maternal imprinting system: Regha, K.; Latos, P.A.; Spahn, L.; Imprinting the Gnas locus: Plagge, A.; Kelsey, G.; The H19 gene: regulation and function of a non-coding RNA: Gabory, A.; Ripoche, M.-A.; Yoshimizu, T.; Dandolo, L.; Imprinting control within the compact Gnas locus: Peters, J.; Holmes, R.; Monk, D.; Beechey, C.V.; Moore, G.E.; Williamson, C.M.; Cross-species clues of an epigenetic imprinting regulatory code for the IGF2R gene: Vu, T.H.; Jirtle, R.L.; Hoffman, A.R.; Imprinting in neurons: Kishino, T.; Analysis of mouse conceptuses with uniparental duplication/deficiency for distal chromosome 12: comparison with chromosome 12 uniparental disomy and implications for genomic imprinting: Tevendale, M.; Watkins, M.; Rasberry, C.; Cattanach, B.; Ferguson-Smith, A.C.; Human Disease; Imprinted genes and their role in human fetal growth: Abu-Amero, S.; Monk, D.; Apostolidou, S.; Stanier, P.; Moore, G.; Imprinted genes in placental growth and obstetric disorders: Tycko, B.; Regulation of growth and metabolism by imprinted genes: Smith, F.M.; Garfield, A.S.; Ward, A.; Imprinting defects on human chromosome 15: Horsthemke, B.; Buiting, K.; The Prader-Willi/Angelman imprinted domain and its control center: Kantor, B.; Shemer, R.; Razin, A.; Imprinting disruption of the CDKN1C/KCNQ1OT1 domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer: Higashimoto, K.; Soejima, H.; Saito, T.; Okumura, K.; Mukai, T.; X Chromosome Inactivation; The dynamics of imprinted X inactivation during preimplantation development in mice: Okamoto, I.; Heard, E.; A SAGE approach to identifying novel trans-acting factors involved in the X inactivation process: Bourdet, A.; Ciaudo, C.; Zakin, L.; Elalouf, J.-M.; Rusniol, C.; Weissenbach, J.; Avner, P.; Evolution of mammalian X chromosome-linked imprinting: Mills, W.; Moore, T.; Author Index.
