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Full Description
The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role.
Contents
Foreword: Stohl, W. Determinations of B Cell Fate in Immunity and Autoimmunity: Noelle, R.J.; Erickson, L.D. Regulatory Roles for Cytokine-Producing B Cells in Infection and Au toimmune Disease: Lund, F.E.; Garvy, B.A.; Randall, T.D.; Harris, D.P. The CD19-CD21 Signal Transduction Complex of B Lymphocytes Regulate s the Balance between Health and Autoimmune Disease: Systemic Scler osis as a Model System: Tedder, T.F.; Poe, J.C.; Fujimoto, M.; Haas, K.M.; Sato, S. Marginal Zone B Cell Physiology and Disease: Lopes-Carvalho, T.; Ke arney, J.F. Dendritic Cells Control B Cell Growth and Differentiation: Jego, G.; Pascual, V.; Palucka, A.K.; Banchereau, J. The Biology of CD20 and Its Potential as a Target for mAb Therapy: Cragg, M.S.; Walshe, C.A.; Ivanov, A.O.; Glennie, M.J. B Lymphocyte Depletion in Rheumatoid Arthritis: Targeting of CD20: Edwards, J.C.W.; Leandro, M.J.; Cambridge, G. Treatment of SLE with Anti-CD20 Monoclonal Antibody: Looney, R.J.; Anolik, J.; Sanz, I. The Biochemistry and Biology of BAFF, APRIL and Their Receptors: Ka lled, S.L.; Ambrose, C.; Hsu, Y.-M. The BAFF/APRIL System: An Important Player in Systemic Rheumatic Di seases: Mackay, F.; Sierro, F.; Grey, S.T.; Gordon, T.P. Human B Lymphocyte Malignancies: Exploitation of BLyS and APRIL and Their Receptors: Jelinek, D.F.; Darce, J.R. BlySfulness Does Not Equal Blissfulness in Systemic Lupus Erythemat osus: A Therapeutic Role for BLyS Antagonists: Stohl, W. Author Index Subject Index
