Natural Compounds as Drugs (Progress in Drug Research) 〈Vol.65-66〉

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Natural Compounds as Drugs (Progress in Drug Research) 〈Vol.65-66〉

Mitarbeit: Jucker, Ernst/ Petersen, Frank, Amstutz, Rene

ウェブストア価格 ¥75,278（本体¥68,435）
Birkhäuser（2008発売）
外貨定価 EUR 320.99
ポイント 684pt

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製本 Hardcover:ハードカバー版／ページ数 860 p.
言語 ENG
商品コード 9783764386269

基本説明

Highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered. Features - Overview of strategies and screening methods.

Full Description

The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. Together with their derivatives, and synthetic compounds deduced from natural product precursors, they represent a major part of today's pharmaceutical market.

In molecular biological research, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors.

This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.

From the contents

Mother nature's gifts to diseases of man: The impact of natural products on anti-infective, anticholestemics and anticancer drug discovery.- Drug discovery and development with plant-derived compounds.- Evolutionary mechanisms underlying secondary metabolite diversity.- Biodiversity, chemical diversity and drug discovery.- High impact technologies for natural products screening.- Virtual screening for the discovery of bioactive natural products.- Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentation.- Nutritional and engineering aspects of microbial process development.- Natural products from plant cell cultures.- Activation of fungal silent gene clusters: An new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.