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Full Description
In Vivo Models of Inflammation provides the biomedical researcher with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research.
New approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has also been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells.
The aim of this book is to provide current best practices for obtaining the maximum information from in vivo experimentation, while preserving the dignity and comfort of the animal.
Contents
Rat models of arthritis: Similarities, differences, advantages, and disadvantages in the identification of novel therapeutics.- Murine collagen induced arthritis.- Use of animal models of osteoarthritis in the evaluation of potential new therapeutic agents.- Models of inflammatory processes in cancer.- Advances in stem cell research: use of stem cells in animal models of muscular dystrophy.- Gene transfer technology.- Transgenics.- Nanotechnology: Towards the detection and treatment of inflammatory diseases.- UK legislation of in vivo aspects in inflammation research.- Japanese guidelines and regulations for scientific and ethical animal experimentation.- United States guidelines and regulations in animal experimentation.
