Full Description
This book brings together articles on the overarching theme of how the environment shapes the immune system.
The immune system is commonly assumed to respond to harmful pathogens such as bacteria and viruses. However, harmless bacteria, chemicals, stress, normal food and other factors can also trigger, shape or interfere with the immune system, often producing adverse effects. Yet, it is also becoming increasingly accepted that some of these interactions are physiological and necessary for a healthy immune system.
Examples of negative effects include the immunosuppressive effects of UV irradiation, or the immunotoxic effects of man-made chemicals such as polycyclic aromatic hydrocarbons. Autoimmunity or allergies can be the adverse consequences of interaction between the immune system and chemical compounds such as drugs. Positive effects can come from natural exposure levels to bacteria, healthy life-style or the diet.
There is a great need to understand how communication between the environment and the immune system works. This book addresses this need. It covers environmental factors (such as bacteria, sun exposure), human factors (such as age, exercise or stress), and important man-made factors (such as air pollution). A chapter on human rights complements the scientific chapters. The book is intended for immunologists, toxicologists and researchers who want to know how the immune system works and is triggered, as well as for medical doctors in environmental medicine and the general public interested in immunology.
Contents
Preface.- Principal players and structure of the immune system.- Immunosuppression by UV-irradiation.- "Eat your veggies" How food-derived AhR ligands are necessary for the development of a functioning gut immune system.- The "Hygiene Theory" - how the immune system learns its balance by exposure to the right bacteria.- Immunotoxicity of dioxins.- Toxic dust and the immune system.- Adrenalin, cortisol and Co: Stress and the immune system.- Immunity and depression: Does inflammation affect our mood?- Diabetes and low-level persistent inflammation caused by the environment.- Mechanisms of major immunosuppressive drugs.- The immune system in the young.- Immunity and age - exhaustion of repertoire by immune experience.- Major research models.- Epigenetic imprinting influences on the immune competence.- Contact allergy and life-style.- Chemicals breaking tolerance leading to allergies and autoimmunity.- The challenge of predicting immunotoxic potential of chemicals.- Environmental pollution and industrial accidents such as Bhopal- a human rights perspective.
