Congenital Cytomegalovirus Infection : Epidemiology, Diagnosis, Therapy

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Halwachs-Baumann, G. (EDT)

Springer, Wien（2010/12発売）

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製本 Hardcover:ハードカバー版／ページ数 350 p.／サイズ 40 illus.
商品コード 9783709102077

Full Description

Congenital cytomegalovirus (CMV) infection is the most common intrauterine transmitted viral infection, with a tremendous impact on fetuses and newborns. In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. Since economic aspects are gaining more and more importance in health politics, one chapter is dedicated to this issue in the context of congenital CMV infection. The content is based on the latest scientific findings and written in an understandable manner, allowing persons not working in the field of congenital CMV to also profit from it. Thus, this book is of interest for medical doctors, nurses, midwives, economists, but also for men and women who want to inform themselves about this topic.

1 Long known, long ignored - a brief history of cytomegalovirus research1.1 Beginnings: 1881-19141.2 Between the wars: 1914-19301.3 From 1930 to 19601.4 From 1960 to the presentReferences 2 Virus-host interaction for defence and transmission2.1 The virus2.2 The host2.2.1 Cell types involved in replication and distribution2.2.2 The immune system - strengths and weakness2.2.3 The placenta - a barrier?2.2.4 Cytomegalovirus - placenta - fetus: a slippery slope between defence and transmissionReferences 3 Epidemiology - the influence of socioeconomic differences3.1 Infant mortality as a social mirror3.2 One effect - many causes3.2.1 Maternal aetiology3.2.2 Foetal aetiology3.2.3 Placental aetiology3.3 Epidemiology of congenital CMV infection3.3.1 Congenital CMV and virus strainsReferences 4 Prospects and obstacles of diagnosis4.1 Screening for congenital CMV infection4.1.1 Screening of the mother4.1.2 Screening of the newborn4.2 Diagnosis of congenital CMV infection4.2.1 Prenatal diagnosis4.2.2 Neonatal diagnosisReferences 5 Clinical outcome: acute symptoms and sleeping hazardsThorsten W. Orlikowsky5.1 Relevance of connatal CMV infection for the paediatrician and neonatologist5.2 The tip of the iceberg5.3 Lucky chance by neonatal immune response5.4 Features of symptomatic CMV infection5.5 Timing of infection5.6 Symptoms of the central nervous system in detail5.6.1 Microcephaly5.6.2 Ocular defects5.6.3 Hearing loss5.6.4 Mental and psychomotor retardation5.6.5 Seizures5.7 Unspecific symptoms in detail5.7.1 Temperature instability5.7.2 Perfusion and rash5.7.3 Lung5.7.4 Liver5.7.5 Jaundice5.7.6 Spleen5.7.7 Platelet system5.7.8 Anaemia5.7.9 Gastrointestinal tract5.8 Asymptomatic infection5.9 Differential diagnosisReferences 6 Prevention and therapy - more than trial and error6.1 Antivirals6.1.1 Treatment of pregnant women6.1.2 Treatment of neonates6.2 Passive immunisation6.3 Active immunisation (vaccination)References7 How to save money: congenital CMV infection and the economyEvelyn Walter, Christine Brennig, Vera Schollbauer7.1 Introduction7.2 Methodology7.2.1 Incidence-based approach7.2.2 Cost calculation7.2.3 Cost of sequelae7.3 Cost of illness in Germany7.3.1 Total societal costs7.3.2 Sensitivity analysis7.3.3 Impact through prevention7.4 DiscussionReferences IndexList of contributors