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Full Description
The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field.
Contents
Stella and zygotic reprogramming by Toshinobu Nakamura and Toru Nakano.- Histone variants and reprogramming in early development by Ana Boskovic and Maria-Elena Torres-Padilla.- Epigenetic regulation of pluripotency by polycomb group proteins by Achim Breiling.- PRC1-mediated gene silencing in pluripotent ES cells: function and evolution by Matthias Becker, Nancy Mah, Daniela Zdzieblo, Xiaoli Li, Arvind Mer, Miguel A. Andrade-Navarro, and Albrecht M. Muller.- The Biology and Genomic Localisation of Cytosine Modifications by Gordon R. McInroy, Neil M. Bell, Gabriella Ficz, Shankar Balasubramanian, Wolf Reik and Eun-Ang Raiber.- DNA methylation reprogramming in preimplantation development by Konstantin Lepikhov, Julia Arand, Sarah Fuchs, Jie Lan, Mark Wossidlo, and Jorn Walter.- Epigenetic reprogramming in cancer by Anders M. Lindroth, Yoon Jung Park, and Christoph Plass.- Establishing and Maintaining Pluripotency- An Epigenetic Perspective by Jing Liao and Alexander Meissner.- Glossary
