Full Description
Bone is a sex hormone-dependent organ, which has important
implications for current therapeutic strategies in the
prevention and possible treatment of bone loss in the
elderly. This book contains the proceedings of the Schering
Workshop on "Sex Steroids and Bone." The various chapters by
leading experts give and overall view of current knowledge
on the control of bone hemostasis by sex steroids and new
ideas on how this controlcould be exerted. It was also of
particular concern to integrate a general survey of in vivo
experimentation and histomorphometric evaluation of bone
tissue. The organizers of the workshop and editors of this
volume hope that it will contribute to a better
understanding of the role of sex steroids in bone and thus
pave the way for a better experimental approach instudying
drug effects on bone with the ultimate goal of improving
therapy in bone diseases.
Contents
1 View of a Clinician: Sex Steroids and Osteoporosis.- 2 The Anabolic Action of Estrogen on Rat Bone.- 3 Progesterone and Its Role in Bone Remodelling.- 4 The Effect of Sex Steroids on Calciotropic Hormones In Vivo.- 5 Effects of Estrogen on Growth Factors in Bone.- 6 Estrogens, Cytokines, and Bone Metabolism.- 7 Sex Steroids and Prostaglandins in Bone Metabolism.- 8 Animal Models for Osteoporosis.- 9 The Rat as an Animal Model of Postmenopausal Bone Loss.- 10 Histomorphometric Studies of Bone Changes in Ovariectomized Rats and Their Prevention by Estrogen Replacement.- 11 Biochemical Assessment of Bone Metabolism in Rodents.
