Full Description
Knowledge of the juxtaglomerular apparatus (JGA) of the kidney and of the synthesis and secretion of renin has increased to such an extent over the past few years that it is now appropriate to summarize this knowledge in a monograph on the JGA, the first of its kind. It was the authors' special concern to demonstrate the association between structure and function for renin secretion, not only within the juxtaglomerular region, but also in the region of the renal cortex beyond the JGA. The description of the pathology of the human JGA, studded with references to experimental findings but nevertheless fully self-contained, should help to make this monograph also useful for clinicians.
Contents
Contents: The Juxtaglomerular Apparatus - History of a Concept.- Morphology of the Juxtaglomerular Apparatus.- Elements with Structural and/or Functional Relationships to the Juxtaglomerular Apparatus.- Intrarenal Distribution of the Different Components of the Renin-Angiotensin System.- Synthesis and Traffic of Renin in Epithelioid Cells.- Morphology of Renin Release from Epithelioid Cells.- Physiology, Pathophysiology, and Biochemistry of Renin Secretion.- Electrophysiology of Epithelioid Cells.- Intrarenal Renin-Angiotensin System.- Metaplastic Transformation Between Smooth Muscle Cells and Epithelioid Cells.- Long-Term Modulation of Renin Synthesis and Secretion.- Interspecies Variations of the Juxtaglomerular Apparatus in Mammals.- Phylogeny and Ontogeny of the Juxtaglomerular Apparatus.- Pathology of the Human Juxtaglomerular Apparatus.- References.- Subject Index.
