Full Description
Provided here is a comprehensive examination of the basic
and clinical condition of three innovative and promising
approaches to cancer therapy, which may support or even
substitute chemotherapy: differentiation, immunomodulation,
and inhibition of angiogenesis.
Differentiation shouldnormalize neoplastic cells and make
them compatible with the host. Its feasibility with
retinoids, interferons, chemotherapeutic and other agents is
discussed. Modulation by biological agents, cytotoxic
effector cells and drugs is considered in attempts to
boost endogenous antitumour defenses and/or to render
neoplastic cells more susceptible to the immune attack of
the host. Finally, the important aspect of interfering with
tumour blood vessel development and function is taken
into account.
Consideringthe importance that chemotherapy has in cancer
treatment and in view of a more and more integrated
strategy, the relationship between the aforementioned
approaches and chemotherapeutic agents and chemoresistance
is treated in detail.
Contents
Colon cancer cell differentiation as related to methotrexate and 5-fluorouracil resistance.- The control of cell multiplication and differentiation in human myelomonocytic cells.- Signal transduction through the Epstein-Barr virus receptor in human B lymphocytes.- Signal transduction mechanisms as a target for cancer chemotherapy.- Therapeutic approaches for colon cancer based on transcriptional regulation of specific growth factors.- Interferon regulation of differentiation and mechanisms.- Induction of tumor cell differentiation as a mechanism of action of DNA-specific antitumor agents.- ATRA therapy in acute promyelocytic leukemia. A model for differentiation therapy.- Hemin is transported in human leukemia K562 cells and interacts with DNA sequences.- Immunomodulation by anticancer drugs in therapeutics.- Differential effects of low doses of structurally different anthracyclines on immunoglobulin production by mouse hybridoma B cells.- Chemical xenogenization of experimental tumors by antineoplastic drugs.- Reversal of drug resistance: synergistic anti-tumor cytotoxic activity by combination treatment with drug and TNF or toxins.- Immunomodulation in cancer patients treated with interleukin-2. Induction of non-specific and specific immune responses.- Potential role of tumor cell antigen modulation in cancer immunotherapy.- Effects of tumor necrosis factor-alpha on growth and doxorubicin sensitivity of multidrug resistant tumor cell lines.- Activation of macrophages by treatment of rat peritoneal cells with photofrin II and He-Ne laser 209.- Synergistic interaction between simvastatin and antineoplastic drugs on glioma cell growth.- CNS and cardiovascular effects of TNF-alpha.- Angiogenesis and angiogenesis factors in stages of carcinogenesis.- Cytokine regulation oftumor-associated macrophages: therapeutic implications.- The mechanism of lectin-mediated adhesion of human ovarian carcinoma cells.- Inhibitory effect of suramin and heparin-like drugs on experimental angiogenesis.- Role of gangliosides in the modulation of the angiogenic response.
