Full Description
Since the thalidomide (Contergan) tragedy about 30 years ago
the induction of prenatally-induced morphological or
functional defects has been an area of extensive research.
Risk assessment of prenatally-induced adverse health effects
is still a difficult task from both experimental data as
well asfrom observations in humans. In the contributions to
this book three major aspects are dealt with:
- Quantitative extrapolations of experimental data to the
situation possibly relevant for man.
- The significance for a risk assessment with respect to man
of minor or rare structural abnormalities observed in
experimental studies
- The future need to assess congenital dysfunctions (e.g. of
the hormone or the immune system) beside the present
evaulation of structural defects.
Limitations as well as gaps of the present knowledge in this
area of basic and applied research are pointed out. Since
the results of prenatally-induced lesions may manifest
themselves not only pre- but often not before late
postnatally, numerous aspects of structural and functional
abnormaldevelopment must be studied in experimental and
clinical investigations.
Contents
Risk Assessment for Pharmaceutical Products.- Reproductive Toxicity Risk Assessment — Some Questions.- Biomarkers of Developmental Neurotoxicity.- A Call for Increased Flexibility in Current Teratogenicity Testing.- Specific and Non-Specific Developmental Effects.- Assessment of Reproductive Toxicology of Drugs at the Food and Drug Administration.- New Approaches to Developmental Toxicity Risk Assessment at the U.S. Environmental Protection Agency.- Scientific Basis for Risk Assessment (Reproductive Toxicity) for Pesticides as Practiced by the Bundesgesundheitsamt (BGA).- Scientific Basis for Risk Assessment (Reproductive Toxicity) in Ecotoxicology as Practiced by the Federal Environmental Agency (Umweltbundesamt).- General Discussion: Choice of Species.- Scientific Basis for Risk Assessment (Reproductive Toxicity) for Medicinal Products as Practiced in Germany and the European Community (EC).- Risk Assessment in Reproductive Toxicology as Practiced in South America.- Reproductive Hazard Evaluation and Risk Assessment under California's Proposition 65.- General Discussion: Risk Assessment.- Statistical Problems (and Some Solutions) Associated with Testing for Effects in Developmental Toxicology.- Aspects of Concentration-Response Analysis.- Dose-Response Relationships in Reproductive Toxicology: Importance of Skeletal Variations.- Prenatal-Toxic Risk Estimation Based on Dose-Response Relationships and Molecular Dosimetry.- Kinetic Problems Arising in a Multigeneration Study.- Application of Mathematical Dose-Response Models vs. Physiological Models in Risk Assessment in Reproductive Toxicology.- General Discussion: Use of Biologically Based Models.- Pharmacoknetics and Drug Metabolism in the Design and Interpretation of Developmental Toxicity Studies.- Feasibilityof Studying Effects on the Immune System in Non-Human Primates.- Marmosets (Callithrix jacchus) as Useful Species for Toxicological Risk Assessments.- Planning and Performance of Segment I, II and III Experiments: Practical Aspects and General Comments.- Significance of Postnatal Manifestations of Prenatally-Induced Effects (Behaviour).- Significance of Prenatally or Early Postnatally-Induced Organ Dysfunctions — Other than CNS Defects.- Quantitative Morphological Tests for Evaluation of Testicular Toxicity.- Morphological Changes in Cultures of Hippocampus Following In Vitro Irradiation.- Possible Contribution of In Vitro Methods to Risk Assessment in Reproductive and Developmental Toxicology.- Morphological Endpoints in In Vitro Testing.- Significance of Epidemiological Studies for Risk Assessment in Prenatal Toxicity.- Maternal Thyroid Autoantibodies and Fetal Thyroid Growth.- Pre- and Postnatal Risk Factors for the Development of Atopy in Childhood.- Does Smoking During Pregnancy Alter Brain Perfusion in the Neonate? A Doppler Study.- Risk Assessment of Tocolytic Therapy in Pregnancy.- Histochemical and Immunocytochemical Investigations of the Fetal Extravascular and Vascular Contractile System in the Normal Placenta and During Preeclampsia.- Some Data on the Pattern of Lymphocyte Subsets in Blood During the Perinatal Period.
