Full Description
Advanced Renal Cell Carcinoma (RCC) cannot be cured by
surgery alone. Its resillience to irradiation and
chemotherapy demands a new approach to the management of
this disease.
This book
provides an overview of the scientific and clinical
developments of RCC,
and clarifies the fields ofimmunotherapy and
immunobiology.
The book contains a compilation of approaches that will
enhance the effectiveness of the management of advancedRCC,
even in the absence of definitive pre-clinical data. These
require additional study and will stimulate the reassessment
of preliminary results.Furthermore, preliminary results
of already implemented clinical trials withbiological
modifiers are presented. Of special interest are the current
achievements in the
field of immunotherapy using topically and subcutaneously
low dosage combinations of cytokines.
This concise volume
will benefit those seeking a thorough review of the research
and the clinical aspects of RCC simultaneously.
Contents
Molecular and Cellular Basis of Renal Cell Carcinoma.- Molecular Differential Pathology of Renal Cell Tumors.- Pathobiology of Renal Carcinogenesis.- Molecular Analysis of DNA Sequences on Chromosome 3 in Patients with Renal Cell Carcinoma.- Cell Proliferation and Cellular Heterogeneity in Renal Cell Carcinoma.- 31P NMR Spectroscopy of Human Tumor Cells In Vitro and In Vivo: Prospects for Applications to Renal Cell Carcinoma.- Conservative Surgery of Renal Tumors: Operative Technique, Complications, Results, DNA Cytometry.- Clinical Relevance of Proliferation Rates in Renal Cell Carcinoma.- Chemotherapy of Renal Cell Carcinoma.- Cytotoxic Chemotherapy Phase II Trials Between 1983 and 1990 for Advanced Renal Cell Carcinoma.- Modulation of Multidrug Resistance in Human Renal Cell Carcinomas.- Transgenic Mice Carrying the Human MdR 1 Gene: Reliable In Vivo Probes to Examine Multidrug Resistance.- Adhesion Molecules and Their Possible Influence on Immune Surveillance.- Immunobiology of Renal Cell Carcinoma.- Anti-Proliferative and Anti-Tumor Effect of a-Interferon in Renal Cell Carcinoma: Correlation with the Expression of a Kidney Associated Differentiation Glycoprotein.- Prediction of Cytokine-Therapy on Basis of Class-I and Class-II MHC Antigen Induction.- Alien Gene Transfection and the Immune Response to Tumors.- Active Specific Immunotherapy with Tumor Cells Expressing a Foreign Gene.- Novel Monoclonal Antibody 138H11 Against Human ?-Glutamyl-Transferase: Classification, Histogenesis and Immunoscintigraphy of Renal Tumors.- T-Cell Activation by Bispecific Monoclonal Antibodies for Lysis of Renal Cell Carcinoma In Vitro.- Immunotherapy of Renal Cell Carcinoma.- New Experimental Approaches to the Adoptive Immunotherapy of Cancer: Cytokines, Gene Therapy, Oncogenes andTransgenic Mice.- Cytokines as Possible Adjuvants to Vaccines in Active Specific Immunotherapy for Renal Cell Carcinoma.- Tumor Infiltrating Lymphocytes in Renal Cell Cancer.- Combined Vaccination with Autologous Tumor Material and Subcutaneously Administered rIL-2 and rIFN-?-2b in the Treatment of Renal Cell Carcinoma.- Interleukin-2 by Inhalation: Local Therapy for Metastatic Renal Cell Carcinoma.
