Full Description
It is about 15 years since the first presentation on uteroglobin was given to a group of developmental biologists, reproductive physiologists, and geneticists who had gathered in November 1966 at Konstanz (Germany). In the following decade so much knowledge was accumulated that a special symposium seemed appropriate. This was organized as a satellite symposium to the International Congress of Endocrinology at Hamburg and brought together 50 scientists at Aachen. These scientists, working in the field of pro teins and steroids, in early pregnancy, recognized the impact of what had been reported, and many of them later agreed to contribute to this booN. and thus to present their research d,!ta available until December 1980. The present volume covers a relatively broad spectrum of data and observations which shed some light on preimplantational embryonic life and on the supports and obstacles provided by the maternal organism with respect to final accomplishment of normal im plantation and establishment of pregnancy. The book will serve both as a textbook and as a scientific dictionary for Ph.D. students, postdoctoral fellows and advanced scientists working in this area. The course of early pregnancy depends very much on a proper balance of steroid hor mones, and the induction of protein synthesis by steroid hormones is one of the well known fundamental processes in cellular differentiation and embryonic development.
Contents
I. The Endocrine and Topographic Basis.- Proteins and Steroids in Early Pregnancy: General Considerations.- Ultrastructure of Trophoblast-Epithelium Relations During Implantation.- Hormonal Control of Decidualization.- Ultrastructural Observations on Luteal Cells and Interstitial Gland Cells During Pseudopregnancy.- II. The Protein Secretion in Early Pregnancy.- Uteroglobin and Other Endometrial Proteins: Biochemistry and Biological Significance in Beginning Pregnancy.- Localization of Uteroglobin and Related Secretion Proteins in Oviducal, Uterine and Blastocyst Cells.- Uteroglobin as a Sensitive Indicator for the Biological Activity of Progestogens.- Prefertilization Progesterone Treatment: Effect on Endometrium, Uteroglobin Secretion and Embryonic Development.- Evidence for the Existence of Human Uteroglobin?.- III. The Synthetic Machinery and Steroid-Protein Interactions.- Studies on Uteroglobin Messenger RNA.- Structure and Binding Properties of Rabbit Uteroglobin. Search for a Similar Protein in Human Uterine Fluid.- Steroid Binding to Uteroglobin.- Steroid Receptors in the Genital Tract and the Monitoring of Steroid Hormone Action.- IV. The Actions and Reactions of the Embryonic System.- The Synthesis of Steroids and Proteins in the Pig Blastocyst.- Steroid Hormones in Blastocyst Tissue, Uterine Flushings, and Endometrium of Pig, Sheep, and Cow.- Proteases of the Blastocyst and of the Uterus.- Embryo-Associated Plasminogen Activator Prior to and During Implantation in the Mouse.- Postfertilization Activation of Stored Maternal mRNA in the One-Cell Mouse Egg.- The Control of Blastocyst Activity.- V. Embryo-Maternal Interactions and Exogenous Interference.- Cellular and Molecular Aspects of Decidualization and Implantation.- Pharmacological Aspects of Early Pregnancy and Contraception.- Antifertility Effect of a Long-Acting Progestin (3-Cyclopentyl Propionate of Megestrol Acetate): Prematurity of the Endometrium and Accompanying Changes of Uteroglobin and Progesterone in Uterine Fluid.
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