Full Description
Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.
Contents
Genetic Modification of Xenografts.- Public Health Risks — Patient vs. Society in an Emerging Field.- Cross-Species Infections.- Non-Human Primate Herpesviruses: Importance for Xenotransplantation.- Understanding Xenotransplantation Risks from Non-Human Primate Retroviruses.- Exogenous Porcine Viruses.- Swine Hepatitis E Virus: Cross-Species Infection and Risk in Xenotransplantation.- Molecular Cloning and Functional Characterization of Infectious PERVand Development of Diagnostic Tests.- Xenotransplantation
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Federal Regulatory Considerations.
