Description
(Table of content)
Experimental Hepatotoxicity.- A. Introductory Considerations.- B. Historical Aspects.- C. Relevance of Experimental Hepatotoxicity.- D. Vulnerability of the Liver to Toxic Injury.- E. Types of Experimental Models.- F. Types of Toxic Hepatic Injury.- G. Classification of Hepatotoxins.- H. Direct Hepatotoxins.- I. Indirect Hepatotoxins.- K. Concluding Comments.- Appendix. Meaning of Abbreviations.- References.- Liver Disease Due to Infection and Allergy.- A. Introduction.- B. Liver Disease Due to Infection.- C. Classical Human Viral Hepatitis.- D. Liver Disease Associated with Autoimmune Reactions.- E. Experimental Models of Chronic Hepatitis.- F. Liver Diseases Associated with Drug Reactions.- G. Conclusion: Immunology and the Liver.- Abbreviations.- References.- Radiation-Induced Injury of the Liver.- A. Introduction.- B. Preliminary Remarks.- C. Radiation-Induced Changes of the Human Liver.- D. Experimental Investigations of the Radiation Effect.- Abbreviations.- References.- Experimental Production of Gallstones.- A. A Fat- and Cholesterol-Free Diet in Hamsters.- B. A Lithogenic Diet Supplemented with Chenodeoxycholic Acid.- C. A High Cholesterol Diet in Prairie Dogs.- D. A Diet Supplemented with D-Thyroxine in Hamsters.- E. A Fat-and Cholesterol-Rich Diet in Squirrel Monkeys.- Abbreviations.- References.- Author Index.ctors in Susceptibility.- d) Experimental Toxicity.- e) Mechanism of Injury.- 6. Dialkylnitrosamines.- a) Significance.- b) Chemical Characteristics.- c) Factors in Susceptibility.- d) Toxic Effects.- e) Metabolism of DMN and Mechanism of Injury.- 7. Tannic Acid.- a) Significance.- b) Chemical Properties.- c) Injury in Humans.- d) Experimental Toxicity.- e) Factors in Susceptibility.- f) Acute Injury.- g) Chronic Toxicity.- h) Mechanism of Injury.- 8. Aflatoxins.- a) Significance.- b) Chemical Characteristics.- c) Sources.- d) Factors in Susceptibility.- e) Hepatic Injury.- f) Mechanism of Hepatic Injury.- 9. Pyrrolidizine Alkaloids.- a) Significance.- b) Chemical Characteristics.- c) Injury in Humans.- d) Factors in Susceptibility.- e) Experimental Toxicity.- f) Mechanism of Injury.- 10. Hepatotoxic Principles of Mushrooms.- a) Significance.- b) Chemical Characteristics of Toxic Principles.- c) Factors in Susceptibility.- d) Toxicity for Humans.- e) Experimental Studies.- f) Mechanism of Injury.- g) Prevention of Toxicity.- 11. Galactosamine.- a) Significance.- b) Chemical Characteristics.- c) Factors in Susceptibility.- d) Experimental Hepatotoxicity.- e) Mechanism of Injury.- 12. Orotic Acid.- a) Significance.- b) Chemical Characteristics.- c) Factors in Susceptibility.- d) Experimental Injury.- e) Mechanism of Injury.- II. Cholestatic Indirect Hepatotoxins.- 1. Icterogenin.- a) Chemical Properties.- b) Experimental Models.- c) Factors in Susceptibility.- d) Toxic Effects.- 2. Sporidesmin.- 3. ?-Naphthylisothiocyanate (ANIT).- a) Significance.- b) Chemical Characteristics.- c) Experimental Models.- d) Factors in Susceptibility.- e) Toxic Effects.- f) Mechanism of Injury.- K. Concluding Comments.- I. Toxins of Living Origin.- II. Toxins of Non-Living Origin.- Appendix. Meaning of Abbreviations.- References.- Liver Disease Due to Infection and Allergy.- A. Introduction.- B. Liver Disease Due to Infection.- I. Multicellular Parasites.- 1. Cestodes.- 2. Trematodes
Contents
Experimental Hepatotoxicity.- A. Introductory Considerations.- B. Historical Aspects.- C. Relevance of Experimental Hepatotoxicity.- D. Vulnerability of the Liver to Toxic Injury.- E. Types of Experimental Models.- F. Types of Toxic Hepatic Injury.- G. Classification of Hepatotoxins.- H. Direct Hepatotoxins.- I. Indirect Hepatotoxins.- K. Concluding Comments.- Appendix. Meaning of Abbreviations.- References.- Liver Disease Due to Infection and Allergy.- A. Introduction.- B. Liver Disease Due to Infection.- C. Classical Human Viral Hepatitis.- D. Liver Disease Associated with Autoimmune Reactions.- E. Experimental Models of Chronic Hepatitis.- F. Liver Diseases Associated with Drug Reactions.- G. Conclusion: Immunology and the Liver.- Abbreviations.- References.- Radiation-Induced Injury of the Liver.- A. Introduction.- B. Preliminary Remarks.- C. Radiation-Induced Changes of the Human Liver.- D. Experimental Investigations of the Radiation Effect.- Abbreviations.- References.- Experimental Production of Gallstones.- A. A Fat- and Cholesterol-Free Diet in Hamsters.- B. A Lithogenic Diet Supplemented with Chenodeoxycholic Acid.- C. A High Cholesterol Diet in Prairie Dogs.- D. A Diet Supplemented with D-Thyroxine in Hamsters.- E. A Fat-and Cholesterol-Rich Diet in Squirrel Monkeys.- Abbreviations.- References.- Author Index.
