Full Description
This book will provide latest insights in the functional potentials of ribonucleic acids in medine and the use of Spiegelmer and Spiegelzyme systems. It will also deal with a new type of delivery systems for cellular targeting.
Contents
Introduction.- RNA Nanotechnology: methods for synthesis, conjugation, assembly and application of RNA nanoparticles.- Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion.- Electrogenerated chemiluminescence of conjugated polymer films from patterned electrodes.- Use of RNA structure flexibility data in nanostructure modeling.- Informatic resources for identifying and annotating structural RNA motifs.- A nanostructure made of a bacterial noncoding RNA.- HAPIscreen, a method for high-throughput aptamer identification.- Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA.- Bifacial nucleoside as a surrogate for both T and A in duplex DNA.- Functionally important structural elements of U12 snRNA.- Self-assembling RNA nanorings based on RNAI/II inverse kissing complexes.- Automatic molecular weaving prototyped by using single-stranded DNA.- Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons.- Nanotextured Substrates With Immobilized Aptamers for Cancer Cell Isolation and Cytology.- Targeting cancer with peptide aptamers.- Synthetic, biofunctional nucleic acid-based molecular devices.- Inducible site-selective bottom-up assembly of virus-derived nanotube arrays on RNA-equipped wafers.- Special delivery: targeted therapy with small RNAs, RNAi nanomedicines: challenges and opportunities within the immune system.- Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and nanotechnology.- Stabilizing RNA by the sonochemical formation of RNA nanospheres. Sonochemical synthesis of DNA nanospheres.- Nucleic acid based molecular devices.- Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case study.- A sol-gel-based microfluidics system enhances the efficiency of RNA aptamer selection.- Hierarchical nanotextured microelectrodes overcome the molecular transport barrier to achieve rapid, direct bacterial detection.- Recent developments in lipid-based pharmaceutical nanocarriers.- Targeted delivery of RNAi therapeutics for cancer therapy.- DNAsomes: Multifunctional DNA-based nanocarriers.- Reversible and Controllable Nanolocomotion of an RNA-Processing Machinery.- Scavenger receptors mediate cellular uptake of polyvalent oligonucleotide-functionalized gold nanoparticles.- A highly sensitive microRNA biosensor based on ruthenium oxide nanoparticle-initiated polymerization of aniline.- Preparation and high-resolution microscopy of gold cluster labeled nucleic acid conjugates and nanodevices.- Kinetically grafting G-quadruplexes onto DNA nanostructures for structure and function encoding via a DNA machine.- Synthesis of glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers.- Cancer immunotherapy and nanomedicine.- RNA nanotechnology: inspired by DNA.- From nanotechnology to nanomedicine: applications to cancer research.- Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery.- Advances in novel drug delivery strategies for breast cancer therapy.- DNA origami: a history and current perspective.- Nanoparticles: a promising modality in the treatment of sarcomas.- Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication.- Recent developments in oligonucleotide conjugation.- In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers.- DNA and carbon nanotubes as medicine.- LHRH-targeted nanoparticles for cancer therapeutics.- Nanoparticle-aptamer conjugates for cancer cell targeting and detection.- Evaluation of targets for ovarian cancer gene silencing therapy: in vitro and in vivo approaches.- Prediction and design of DNA and RNA structures.- siRNA applications in nanomedicine.
