Targeting Functional Centers of the Ribosome (Springer Theses) （2011）

Davidovich, Chen

Springer-Verlag Berlin and Heidelberg GmbH & Co. K（2013/04発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 74 p.
• 言語 ENG
• 商品コード 9783642267055
• DDC分類 571.658

Full Description

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

Contents

Introduction.- Methods.- Results.- Discussion.