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Full Description
Comprehensive introduction to the design principles, response mechanisms, and imaging applications of organic small-molecule fluorescence probes
Fluorescent Probes for Bioactive Species provides a systematic primer for organic small-molecule fluorescence probes. The book starts by discussing the principles of molecular recognition, the phenomenon of fluorescence luminescence, and fluorescent probes design. Each chapter of the book is separated based on the classification of biologically active species. Instead of gathering all of the related fluorescent probes for a typical analyte, the book mainly focuses on the representative probes that present new recognition mechanisms and the related optimization theories to realize better detection and imaging.
In each chapter, the relationship and differences between the complex biomolecules of the species are discussed. The corresponding pros and cons of the recognition mechanisms based on these structural or reactive differences create the core of each section's discussion. Finally, the specifics of biological sample-oriented design and development of fluorescent probes are discussed.
Fluorescent Probes for Bioactive Species includes information on:
Excitation modes of fluorescent probes, fluorescence reporting modes, and optical modulation mechanisms of fluorescent probes
Fluorescent probes of hydrogen peroxide (H2O2), hypochlorous acid (HCiO), hydroxyl radical (OH), superoxide anion (O&ndash2), and singlet oxygen (1O2)
Synthesis, recognition mechanism, and bioimaging of norepinephrine probes, dopamine probes, acetylcholine probes, glutamic acid, 5-hydroxytryptamine, and histamine
Active molecules and enzymes of dual-responsive fluorescent probes
Biological functions of reactive sulfur species (RSS)
Fluorescent Probes for Bioactive Species is an essential, up-to-date reference for chemists, scientists, and professionals in the sensor industry seeking to promote the development of new tools for biomonitoring and develop a deep understanding of mysterious biological events.
Contents
Preface xiii
Acknowledgment xv
1 Fluorescence and Molecular Recognition 1
Weijie Zhang and Laraib
2 Fluorescent Probes 19
Ying Wen and Xiaobei Yan
3 Fluorescence Probe of Reactive Oxygen Species 41
Yongchuang Li, Pei Huang, Yiran Qi, Tian Lv, and Haiyue Liu
4 Fluorescent Probe of Reactive Sulfur Species 83
Junping Wang, Xinya Niu, Jingdong Wang, Waqas Pervez, and Rizwana Asghar
5 Fluorescent Probes for Reactive Nitrogen Species 163
Qian Pang and Lipeng Zhang
6 Fluorescent Probes for Reactive Carbon Species 193
Wenjiao Wu and Yuting Wang
7 Fluorescent Probes for Oxidoreductase Enzymes 215
Xinyu Li and Xingwei
8 Fluorescent Probes for Neurotransmitters 243
Huming Yan and Na Zhou
9 Dual-response Fluorescent Probes for the Above Reactive Species 261
Shiyu Wang and Xinfeng Zhang
10 Other Bioactive Species Fluorescent Probes 319
He Yang and Peipei Liu
11 Summary 349
Muhammad Nouman Nazeer
Index 355
