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Full Description
Comprehensive introduction to the design principles, response mechanisms, and imaging applications of organic small-molecule fluorescence probes
Fluorescent Probes for Bioactive Species provides a systematic primer for organic small-molecule fluorescence probes. The book starts by discussing the principles of molecular recognition, the phenomenon of fluorescence luminescence, and fluorescent probes design. Each chapter of the book is separated based on the classification of biologically active species. Instead of gathering all of the related fluorescent probes for a typical analyte, the book mainly focuses on the representative probes that present new recognition mechanisms and the related optimization theories to realize better detection and imaging.
In each chapter, the relationship and differences between the complex biomolecules of the species are discussed. The corresponding pros and cons of the recognition mechanisms based on these structural or reactive differences create the core of each section's discussion. Finally, the specifics of biological sample-oriented design and development of fluorescent probes are discussed.
Fluorescent Probes for Bioactive Species includes information on:
Excitation modes of fluorescent probes, fluorescence reporting modes, and optical modulation mechanisms of fluorescent probes
Fluorescent probes of hydrogen peroxide (H202), hypochlorous acid (HCiO), hydroxyl radical (OH), superoxide anion (), and singlet oxygen (1O2)
Synthesis, recognition mechanism, and bioimaging of norepinephrine probes, dopamine probes, acetylcholine probes, glutamic acid, 5-hydroxytryptamine, and histamine
Active molecules and enzymes of dual-responsive fluorescent probes
Biological functions of reactive sulfur species (RSS)
Fluorescent Probes for Bioactive Species is an essential, up-to-date reference for chemists, scientists, and professionals in the sensor industry seeking to promote the development of new tools for biomonitoring and develop a deep understanding of mysterious biological events.
Contents
Chapter 1: Fluorescence and molecular recognition
1.1 Advancing fluorescence theory
1.2 Advancing fluorescent dyes
1.3 Advancing fluorescent recognition
Chapter 2: Fluorescent probes
2.1 Excitation mode of fluorescent probes: single photon/two-photon/upconversion
2.2 Fluorescence reporting mode: turn-on/turn-off/ratiometric/lifetime/anisotropy
2.3 Optical modulation mechanism of fluorescent probes:PET/ICT/ESIPT/FRET/AIE
2.4 Design mode of fluorescent probes: reaction type involving the formation and breaking of chemical covalent bonds (such as nucleophilic reactions, oxidation reactions, etc), coordination type, proton-deprotonation type, aggregation-precipitation type, etc.
Chapter 3: Fluorescent probes for reactive oxygen species
3.1 Introduction to biological functions of ROS
3.2 Synthesis, recognition mechanism and bioimaging of H2O2 probes
3.3 Synthesis, recognition mechanism and bioimaging of O2·- probes
3.4 Synthesis, recognition mechanism and practical application of HOCl probes
3.5 Synthesis, recognition mechanism and bioimaging of HO· probes
3.6 Synthesis, recognition mechanism and bioimaging of 1O2 probes
Chapter 4: Fluorescent probes for reactive sulfur species
4.1 Introduction to biological functions of RSS
4.2 Synthesis, recognition mechanism and biomedical application of Cys probes
4.4 Synthesis, recognition mechanism and biomedical application of Hcy probes
4.5 Synthesis, recognition mechanism and bioimaging of GSH probes
4.6 Synthesis, recognition mechanism and bioimaging of H2S probes
4.7 Synthesis, recognition mechanism and bioimaging of SO2 probes
4.8 Synthesis, recognition mechanism and bioimaging of polysulfide probes
Chapter 5: Fluorescent probes for reactive nitrogen species
5.1 Introduction to biological functions of RNS
5.2 Synthesis, recognition mechanism and bioapplication of NO probes
5.3 Synthesis, recognition mechanism and bioapplication of ONOO- probes
5.4 Synthesis, recognition mechanism and bioapplication of S-nitrosothiol
Chapter 6: Fluorescent probes for reactive carbon species
6.1 Introduction to biological functions of RCS
6.2 Synthesis, recognition mechanism and bioimaging of carbon monoxide probes
6.3 Synthesis, recognition mechanism and bioapplication of formaldehyde
6.4 Synthesis, recognition mechanism and bioapplication of ethylene
6.5 Synthesis, recognition mechanism and bioimaging of malonaldehyde probes
Chapter 7: Fluorescent probes for redox-related enzymes
7.1 Brief introduction of enzymes in redox modulation
7.2 Synthesis, recognition mechanism and bioimaging of monoamine probes
7.3 Synthesis, recognition mechanism and biomedical application of NAD(P)H: quinine oxidoreductase probes
7.4 Synthesis, recognition mechanism and bioimaging of nitroreductase probes
7.5 Synthesis, recognition mechanism and bioimaging of tyrosinase probes
7.6 Synthesis, recognition mechanism and bioimaging of thioredoxin reductase probes
7.7 Others
Chapter 8: Fluorescent probes for neurotransmitters
8.1 Biological function of neurotransmitter
8.2 Synthesis, recognition mechanism and bioimaging of norepinephrine probes
8.3 Synthesis, recognition mechanism and bioimaging of dopamine probes
8.4 Synthesis, recognition mechanism and bioimaging of acetylcholine probes
8.5 Synthesis, recognition mechanism and bioimaging of glutamic acid
8.6 Synthesis, recognition mechanism and bioimaging of 5-hydroxytryptamine
8.7 Synthesis, recognition mechanism and bioimaging of histamine
8.8 Other neurotransmitters
Chapter 9: Dual-response fluorescent probes for the above reactive species
9.1 Synthesis, recognition mechanism and bioimaging of dual-response fluorescent probes for RSS
9.2 Synthesis, recognition mechanism and bioimaging of dual-response fluorescent probes for ROS
9.3 Synthesis, recognition mechanism and bioimaging of dual-response fluorescent probes for RSS and ROS
9.4 Synthesis, recognition mechanism and bioimaging of dual-response fluorescent probes for RSS and RNS
9.5 Synthesis, recognition mechanism and bioimaging of dual-response fluorescent probes for RSS and enzyme
9.6 Synthesis, recognition mechanism and bioimaging of dual-response fluorescent probes for ROS and enzyme
9.7 Synthesis, recognition mechanism and bioimaging of dual-response fluorescent probes for two enzymes
9.8 Others
Chapter 10: Other bioactive species fluorescent probes
10.1 Synthesis, recognition mechanism and bioimaging of NAD(P)H
10.2 Synthesis, recognition mechanism and bioimaging of pyruvic acid probes
10.3 Synthesis, recognition mechanism and bioimaging of Lactic acid probes
10.4 Synthesis, recognition mechanism and bioimaging of lipid peroxidation
10.5 Synthesis, recognition mechanism and bioimaging of ATP
10.6 Others
Chapter 11: Summary and outlook
