基本説明
The second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler. The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes new chapters on traditional family studies and state-of-the-art genome-wide association studies.
Full Description
This is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Chapter of the International Biometric Society, and Inke Konig, who has been teaching the subject over many years. The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes new chapters on segregation analysis, twin studies and estimation of heritability. The book is ideally suited for advanced students in epidemiology, genetics, statistics, bioinformatics and biomathematics. Like in the first edition the book contains many problems and solutions.
Contents
INTRODUCTORY GENETICS Molecular Genetics Formal Genetics Genetic Markers Data Quality LINKAGE ANALYSIS AND FAMILY STUDIES Genetic Map Distances Model Based Linkage Analysis Model Free Linkage Analysis for Binary Traits Model Free Linkage Analysis for Quantitative Traits Family Studies not Involving Genetic Markers ASSOCIATION ANALYSIS Fundamental Concepts of Association Analyses Association Analysis with Unrelated Individuals Family Based Association Analysis Haplotypes GWAs Appendix Solutions References
