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Full Description
The book describes the different and exciting pathways which have been developed by pathogenic microbes to manage living inside host cells. It covers intracellular life styles of all relevant pathogenic but also symbiotic microorganisms with respect to the cell biology of the host-microbe interactions and the microbial adaptations for intracellular survival. It features intracellular trafficking pathways and characteristics of intracellular niches of individual microbes. The book also asks questions on the benefits for the microbe with regard to physiological needs and nutritional aspects such as auxotrophy, effects on genome sizes, and consequences for disease and host response/immunity (and the benefits for the host in the cases of symbionts).
Additionally, the book includes those pathogens that are medically less important but represent distinct intracellular niches, trafficking behaviours and virulence traits. The individual chapters also point out future challenges of research for the respective organism.
Contents
Foreword (Sansonetti)
GENERAL ASPECTS
Introduction: The Evolution of Intracellular Life Forms and their Niches (Schaible and Haas)
Limited Genomes and Gene Transfer in the Evolution of Intracellular Parasitism and Symbiosis (Somboonna and Dean)
Phagocytosis: Early Events in Particle Recognition and Uptake (Cosio and Grinstein)
Cellular Model Systems Used to Study Phagosome Biogenesis (Steinert)
Methods Used to Study Phagosome Biogenesis (Haas)
In Vitro Fusion Assays with Phagosomes (Becken and Haas)
Phagosome Proteomes Unite! A Virtual Model of Maturation as a Tool to Study Pathogen-Induced Changes (Dieckmann and Soldati)
Phagosome -
Cytoskeleton Interactions (Gutierrez and Griffiths)
Intracellular Microbe Whole-Genome Expression Profiling: Methodological Considerations and Biological Inferences (Waddell and Butcher)
Everybody Has A Home of Their Own -
The Phagosome Zoo (Haas)
Consequences of Pathogen Compartmentation for Therapeutic Intervention (Haas and Schaible)
The Immune Response to Intracellular Pathogens (Korbel and Schaible)
SELECTED PATHOGENS
VACUOLAR BACTERIA
Afipia felis (Schneider and Haas)
Brucella (Kalde, Moreno, and Gorvel)
Chlamydiae (Hackstadt)
Coxiella burnetii (Gilk, Voth, and Heinzen)
Ehrlichia and Anaplasma (Rikihisa)
Legionella pneumophila (Ingmundson and Roy)
Mycobacterium tuberculosis and His Comrades (Schaible)
Rhodococcus equi and Nocardia asteroides (von Bargen and Haas)
Salmonella (Steele-Mortimer)
INTRACYTOSOLIC BACTERIA
Burkholderia pseudomallei (Stevens and Stevens)
Francisella tularensis (Allen and Schulert)
Listeria monocytogenes (Balestrino and Cossart)
Mycobacterium marinum (Hagedorn and Soldati)
Rickettsia (Sahni, Rydkina, and Silverman)
Shigella (Van Nhieu and Sansonetti)
INTRACELLULAR SYMBIONTS
Bacterial Symbionts of Plants (Kambara, Broughton, and Deakin)
Cyanobacterial and Algal Symbioses (Kovacevic, Steiner, and Loffelhardt)
Insect Symbionts (Feldhaar and Gross)
PARASITES AND FUNGI
Histoplasma capsulatum (Newman)
Leishmania: L. mexicana vs. donovani vs. major;
Amastigotes vs. Promastigotes (Matte, Mallegol, and Descoteaux)
Plasmodium and Babesia (Winterberg, Przyborski, Lingelbach)
Theileria (Dobbelaere and Baumgartner)
Toxoplasma gondii (Sibley)
Trypanosoma cruzi (Taylor)
Trichinella and the Nurse Cell (Guiliano and Oksov)
