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Full Description
This first book to deal with this modern and powerful tool in instrumental analytical chemistry focuses on practical issues, making it a useful guide for both beginners and experienced scientists.
The first part describes the methodological background for the coupling of electromigrative separation techniques with mass spectrometry, discussing various separation techniques, interfacing options and MS detection systems. The second part focuses on method development, applications and aspects of quantification and validation. The whole is rounded off with a look at future developments.
Contents
PART I: METHODOLOGY ELECTROMIGRATIVE SEPARATION MODES COUPLED TO MASS SPECTROMETRY Capillary Zone Electrophoresis (CE) Capillary Gel Electrophoresis (CGE) Capillary Isoelectric Focusing (CIEF) Capillary Electrokinetic Chromatography (CEC) Micellar Electrokinetic Chromatography (MEKC) Isotachophoresis (ITP) Multidimensional Separation Techniques INTERFACES Atmospheric Pressure Ionization (On-Line Coupling) Vacuum Ionization (Off-Line Coupling) MASS SPECTROMETER COUPLED TO ELECTROMIGRATIVE SEPARATION MODES Quadrupole Type Ion Traps Time-Of-Flight FTICR Others PART II: APPLICATIONS METHOD DEVELOPMENT General Considerations Influences of the Sample Composition Preconcentration Techniques Coatings SMALL CATIONIC SUBSTANCES Choice of Electrolyte and Interface Parameter Applications SMALL ANIONIC SUBSTANCES Choice of Electrolyte and Interface Parameter Applications BIOPOLYMERS Intact Proteins Oligonucleotides QUANTITATION AND VALIDATION Quantitation Rubustness and Precision Detection Limits Identification FUTURE DEVELOPMENTS Intrumentation Microchannel Electrophoresis - Mass Spectrometry ("Chip-MS") Applications
