Full Description
This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.
Contents
Introduction Biological Systems Relevant for Redox Signaling and Control Cellular Generation of Oxidants: Relation to Oxidative Stress The Chemical Basis of Biological Redox Control Protein Glutathiolation Structure and Function of the Human Peroxiredoxin-Based Antioxidant System: the Interplay between Peroxiredoxins, Thioredoxins, Thioredoxin Reductases, Sulfiredoxins and Sestrins Hydrogen Peroxide and Cysteine Protein Signaling Pathways Protein Tyrosine Phosphatases as Mediators of Redox Signaling Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1a Eicosanoid-Based Signaling Redox-Controlled Transcription Factors and Gene Expression Nitric Oxide Regulation in Redox Signaling Is Hydrogen Sulfide a Regulator of Nitric Oxide Bioavailability in the Vasculature? Aspects of Nox/Duox Signaling Photodynamic Therapy with Aminolevulinic Acid and Iron Chelators: A Clinical Example of Redox Signaling Oxidative Stress and Apoptosis Redox Regulation of Apoptosis in Immune Cells Redox Control in Human Disease with a Special Emphasis on the Peroxiredoxin-Based Antioxidant System Free Radicals and Mammalian Aging
