基本説明
A practical manual for the small and large-scale preparation of enantiomerically pure products.
Full Description
Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.
Contents
1 Enantiomeric separations using macrocyclic glycopeptide stationary phases
2 The Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis
3 Analytical and preparative potential of immobilized polysaccharide-derived chiral stationary phases
4 Chiral separations using supercritical fluid chromatography
5 Chiral ligand exchange in HPLC and CE
6 Advances in Simulated Moving Bed Chromatographic separations
7 Less common applications of enantioselective HPLC using the SMB technology in the pharmaceutical industry
8 Enatiomer Separation by Chiral Crown Ether Stationary phases
9 Chiral Separation of amino acids and hydroxy acids in HPLC with copper(II) complexes added to the eluent
10 Chiral Capillary Electrophoresis
11 Techniques in preparative chiral separations
12 Separation of enantiomers using molecularly imprinted polymers
13 Enantioselective Biosensors
14 Chiral analysis using CEC-UV and CEC-MS
15 Chiral analysis using MEKC-UV and MEKC-MS
16 Polarimeter Chiral Detectors in Enantioseparations
17 Preparative Chiral Chromatography - a powerful and efficient tool in drug discovery
