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基本説明
Features cellular mechanisms and discusses medical implications, and covers emerging infectious diseases, e.g., tuberculosis.
Description
(Text)
How does autophagy trigger the immune system against intracellular pathogens? This is the first book on an excitingly new topic at the interface of cell biology, immunology, and infection biology. Edited by one of the authors of the groundbreaking papers this title offers a unique insight into a newly recognized immunity mechanism that complements our present view of the how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. After a comprehensive introduction to autophagy it features all major pathogens, also covering emerging infectious diseases, e.g., tuberculosis.
(Table of content)
INTRODUCTION TO AUTOPHAGY
Overview of Autophagy
Cell Biology and Biochemistry of Autophagy
Transgenic Models of Autophagy
Autophagy in Disease and Aging
The Dual Roles for Autophagy in Cell Death and Survival
AUTOPHAGY AND BACTERIA
Autophagy and Mycobacterium Tuberculosis
Autophagy Eliminates Group A Streptococcus Invading Host Cells
Shigella Invasion of Host Cells and Escape from Autophagy
Listeria Monocytogenes: a Model System for Studying Autophagy
Coxiella Burnetii Hijacks the Autophagy Pathway to Survive
Utilization of Endoplasmic Reticulum Membranes to Establish a Vacuole that Supports Replication of Legionella Pneumophila
AUTOPHAGY AND VIRUSES
Endogenous MHC Class II Antigen Processing of Viral Antigens
Autophagy in Antiviral Host Defense
(Author portrait)
Vojo Deretic is full professor and vice-chair at the Department of Molecular Genetics and Microbiology of the University of New Mexico Health Sciences Center. From 1997 to 1999 hewas Foundation Lecturer of the American Society for Microbiology. He published one of the groundbreaking papers on this topic in CELL.
