基本説明
Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background; Distinct structures and functions; Structural basis; Signaling; and more.
Full Description
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail.
Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include:
Historical background
Distinct structures and functions
Structural basis
Signaling
Viral entry and virion budding
Cholesterol transport
Caveolins
Lipid shells
Cell polarity and intracellular trafficking
Cancer cells
Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
Contents
Lipid Rafts, Caveolae, and Membrane Traffic
The Forces that Shape Caveolae
The Biophysical Characterization of Lipid Rafts
The Role of Caveolae and Noncaveolar Rafts in Endocytosis
Role of Cholesterol in Signal Transduction from Caveolae
Phosphorylation of Caveolin and Signaling from Caveolae
Role of Lipid Microdomains in the Formation of Supramolecular Protein Complexes and Transmembrane Signaling
Caveolin and its Role in Intracellular Chaperone Complexes
The Roles of Caveolae and Caveolin in Cell Shape, Locomotion, and Stress Fiber Formation
Lipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor Protein
Caveolae and the Endothelial Nitric Oxide Synthase
The Role of Caveolin-1 in Tumor Cell Survival and Cancer Progression
