Chemogenomics in Drug Discovery : A Medicinal Chemistry Perspective (Methods and Principles in Medicinal Chemistry Vol.22)

Hugo Kubinyi, Gerhard Mueller, Raimund Mannhold et al.

WILEY-VCH（2004発売）

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製本 Hardcover:ハードカバー版
商品コード 9783527309870

Description

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.
This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design.
With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process. From the contents:
IntroductionTARGET FAMILIESGPCRsKinasesNuclear Hormone ReceptorsIon ChannelsPhosphodiesterasesMEDICINAL CHEMISTRY STRATEGIESPrivileged StructuresNatural ProductsDiversity-oriented Organic ChemistrySOSA ApproachTemplate Hopping and Designed Combinatorial ChemistryChemogenomics on a Building Block LevelBinding Site SimilaritiesBioinformatics Meets ChemoinformaticsProteochemometrics
Hugo Kubinyi gehört seit 1985 der BASF AG an, wo Kombinatorische Chemie, Molecular Modelling und Wirkstoffdesign zu seinen Tätigkeitsfeldern zählten. Sein Spezialgebiet sind Struktur-Wirkungs-Beziehungen und QSAR-Methoden.