Full Description
Whilst achievements in antigen presentation research and related biomedical applications have been rapidly accumulating, until now there has been no concise yet sufficiently detailed overview of MHC genetics and molecular processing in one volume. This book adopts a comprehensive approach to antigen presentation, featuring links to cancer research, proteomics, systems biology, and stem cell therapy. In-depth surveys of our current state of knowledge cover both basic research as well as promising novel therapeutic strategies, such as in the treatment of cancer and autoimmune diseases.
Contents
Role of HLA class II molecules in disease and immunity - Chella; MHC genomics and disease - Dawkins; Baroque, neoclassical, and postmodern MHC class I genes - Fischer Lindahl; Antigen presentation by class Ib molecules - Forman; Genomics, proteomics and systems biology - A new approach to immunology - Hood; How many ways to skin a cat? - Howard; Micro-dissection of the immune response to GAD65 in NOD mice - McDevitt; Origin of Antigen Presentation - provisional - Mitchison; Genetic and physical analyses of medaka MHC - Nonaka; HLA and NK immunogenetics - Trowsdale; HLA class I and antigen presentation in cancer cells - Walden; Biology and transplantation of stem and progenitor cells - Weissman; Genetic and immunological analysis of susceptibility to Leishmania major infection - Demant; Antigen Presenting Cells in an MHC Class II Negative Tumor Model - Dembic; MHC genomics - from the proteasome to genome evolution - Kasahara; Diverse functions of HLA-E in regulating innate and adaptive immune responses - Weiss
