Description
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Plasmodium falciparum is the causative agent of the most deadly form of malaria. The life cycle of this parasite is complex and alternates between the mammalian host and the mosquito vector. Extensive usage of current regime of antimalarials over the past few decades has exposed malarial parasites to tremendous selection pressures and they over the course have evolved efficient mechanisms of resistance. This problem is further compounded because of a limited regime of drugs available against the parasite. To overcome this dual problem there is an immediate need to discover new drug targets in the parasite and potentially discover potent drugs against them. This work embodies potential of Malarial parasite apicoplastic Tyrosyl tRNA Synthetase as a potential new Drug target in the war against the parasite.
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