Description
(Text)
Both in vitro and in vivo studies were performed in the present research to investigate the pharmacological effects of successive Nepeta cataria extracts on some biochemical parameters in Streptozotocin diabetic rats compared to the currently used drug, Glicalized. These involved some biochemical parameters such as glucose, insulin, carbohydrate hydrolyzing enzymes; -amylase, - glucosidase, beta- galactosidase, liver steoteosis; total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, total lipid, liver function enzymes; alanin aminotransferase(ALT), aspatrate aminotransferase (AST), alkaline phosphates (ALP) and total protein, oxidative stress markers; NO and DPPH. In addition histopathological investigations were performed. The results obtained revealed that in vitro analysis, different successive extracts of Nepeta cataria exhibited inhibitory effect on oxidative stress indices ( NO and DPPH) and carbohydrate hydrolyzing enzymes ( -amylase, -glucosidase and beta- galactosidase) in linear relationships to some extent with concentration of inhibitors (dose dependant). Total ethanol (70%), petroleum ether and chloroform extracts showed respectively the most potent effects
