The Blood Brain Barrier and Inflammation (Progress in Inflammation Research)

Lyck, Ruth (EDT)/ Enzmann, Gaby (EDT)

Springer International Publishing AG（2017/04発売）

• 製本 Hardcover:ハードカバー版／ページ数 286 p.
• 商品コード 9783319455129

Full Description

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

Contents

General Introduction to Barrier Mechanisms in the Central Nervous System.- Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research.- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions.- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases.- Leakage at Blood-neural Barriers.- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology.- MicroRNAs in Brain Endothelium and Inflammation.- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases.- Pathways Across the Blood Brain Barrier.- Neuroinflammation in Bacterial Meningitis.- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.