山口正義著／細胞ホメオスタシス・障害におけるリグカルシン The Role of Regucalcin in Cell Homeostasis and Disorder （1st ed. 2017. 2017. xv, 385 S. 235 mm）

Yamaguchi, Masayoshi

SPRINGER, BERLIN; SPRINGER INTERNATIONAL PUBLISHING（2017発売）

• 製本 Hardcover:ハードカバー版
• 商品コード 9783319398556

Full Description

This monograph updates readers with the latest findings in biomedical science relating to 'Regucalcin', a protein discovered by the author in 1978 and which proved to be a highly significant discovery. Regucalcin was later demonstrated to possess a pivotal role in cell regulation in various types of cells and tissues. Beginning with an introduction to the discovery of regucalcin, the book then looks at the structure of regucalcin and at translational regulation of the regucalcin gene. Chapters consider the multifunctional role of this protein in cell regulation, including intracellular calcium homeostasis, nuclear function and gene expression, protein synthesis and proteolysis, cell proliferation, apoptosis, and oxidative stress. Furthermore, this book highlights involvements of regucalcin in cell disorder and diseases in implication with liver metabolic disorder, kidney failure, cardiac disorder, brain calcium homeostasis and aging, bone homeostasis and osteoporosis, lipid metabolism and diabetes, and carcinogenesis. Moreover, readers will discover serum regucalcin's potential sensitivity as a specific biochemical marker in various metabolic disorders.This book contributes to scientific understanding of cell disorder and a variety of diseases and it will be of interest to many researchers and graduate students in the field of biomedical sciences.

Contents

Preface Chapter 1. The transcriptional regulation of regucalcin gene expression Chapter 2. Novel transcription factor involved in the regucalcin gene expression Chapter 3. Role of regucalcin as a suppressor in cell signaling Chapter 4. Role of regucalcin in cell nuclear function Chapter 5. Role of regucalcin as a suppressor protein in cell proliferation Chapter 6. Role of regucalcin in rescue of cell apoptosis Chapter 7. Involvement of regucalcin in kidney disorder Chapter 8. Role of regucalcin in brain disorder with ageing Chapter 9. Role of regucalcin in heart failure Chapter 10. Role of regucalcin in bone homeostasis and osteoporosis Chapter 11. Role of regucalcin in lipid metabolism and diabetes Chapter 12. Role of regucalcin in nutritional metabolism Chapter 13. Regucalcin gene therapy in carcinogenesis Chapter 14. Clinical aspects of regucalcin as a biomarker in disease ProspectIndex