Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds (Springer Theses)

McDonald, Stacey L.

Springer International Publishing AG（2016/08発売）

• 製本 Hardcover:ハードカバー版／ページ数 144 p.
• 商品コード 9783319388779

Full Description

This thesis reports the latest developments in the direct amination of various C-H bonds using an H-Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C-H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald's findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

Contents

Electrophilic amination for the synthesis of alkyl and aryl amines.- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates.- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives.-  Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C-H Zincation.