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Full Description
This book presents an overview of the RNA networks controlling gene expression in fungi highlighting the remaining questions and future challenges in this area.It covers several aspects of the RNA-mediated mechanisms that regulate gene expression in model yeasts and filamentous fungi, organisms of great importance for industry, medicine and agriculture. It is estimated that there are more than one million fungal species on the Earth. Despite their diversity (saprophytic, parasitic and mutualistic), fungi share common features distinctive from plants and animals and have been grouped taxonomically as an independent eukaryotic kingdom. In this book, 15 chapters written by experts in their fields cover the RNA-dependent processes that take place in a fungal cell ranging from formation of coding and non-coding RNAs to mRNA translation, ribosomal RNA biogenesis, gene silencing, RNA editing and epigenetic regulation.
Contents
RNA polymerase II-dependent transcription in fungi and its interplay with mRNA decay.- Pre-mRNA splicing and the spliceosome: assembly, catalysis and fidelity.- Fungal pre-mRNA 3' end processing.- mRNA export.- mRNA translation: Fungal variations on a eukaryotic theme.- mRNA localization.- mRNA degradation and decay.- Cytoplasmic mRNA surveillance pathways.- Making Ribosomes: pre-rRNA Transcription and Processing.- Biogenesis and evolution of functional tRNAs.- Small RNA-mediated gene silencing in Neurospora.- The RNAi machinery in Mucorales: the emerging role of endogenous small RNAs.- Regulation of pericentric heterochromatin by ncRNA in Schizosaccharomyces pombe.- Approaches for dissecting RNA-binding protein networks.- Bioinformatic tools for Next-Generation RNA sequencing analysis.
