Full Description
This textbook will provide a comprehensive, state-of-the art review the field of diagnostic hematopathology as it's applied to patients with plasma cell neoplasms. Particular emphasis will be placed on immunophenotypic data - immunohistochemistry and flow cytometry - as well as cytogenetics. We will also discuss how these ancillary data can predict prognosis and chemotherapeutic response. Plasma Cell Neoplasms will serve as a very useful resource for physicians and researchers interested in the plasma cell myeloma diagnosis, therapy, and research. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.
Contents
Introduction.- Protein studies.- Electrophoresis and immunofixation.- Serum free light chain analysis.- Morphology and immunohistochemistry of normal and neoplastic plasma cells.- Classification of plasma cell neoplasms.- Monoclonal gammopathy of undetermined significance.- Plasma cell myeloma.- Plasmacytoma - solitary and extraosseus.- Monoclonal immunoglobulin deposition diseases.- Cytogenetics.- Flow cytometry.- Integration of laboratory and clinical data into synoptic report.- Approaches to treatment, including stem cell transplant.- Conclusions.- References.
