Gene Prioritization : Rationale, Methodologies and Algorithms (SpringerBriefs in Systems Biology) （2014. 2014. xii, 66 S. 9 SW-Abb., 21 Farbabb. 235 mm）

Masoudi-Nejad, Ali/ Meshkin, Alireza

SPRINGER, BERLIN; SPRINGER INTERNATIONAL PUBLISHING（2014発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 79 p.
• 言語 ENG
• 商品コード 9783319046860

Full Description

Identifying causal genes underlying susceptibility to human disease is a problem of primary importance in the post-genomic era and in current biomedical research. Recently, there has been a paradigm shift of such gene-discovery efforts from rare, monogenic conditions to common "oligogenic" or "multifactorial" conditions such as asthma, diabetes, cancers and neurological disorders. These conditions are referred to as multifactorial because, susceptibility to these diseases is attributed to the combinatorial effects of genetic variation at a number of different genes and their interaction with relevant environmental exposures. The goal of this book is to introduce gene prioritization aspects and the candidate gene prioritization algorithms to give readers a comprehensive view on the subject.

Contents

Gene Prioritization Concepts.- Gene Prioritization Rationale.- Evaluations Methods for Gene Prioritization.- Gene Prioritization algorithms.- Successes.- Non-networked-based apoproaches.- Network-based approaches.- Conclusions.