Full Description
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty. This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
Contents
Preface: Extermann, M.; Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging, or Vice Versa?: Sharp, Z.D.; Curiel, T.J.; Livi, C.B.; Senescent Cells and Their Secretory Phenotype as Targets for Cancer Therapy: Velarde, M.C.; Demaria, M.; Campisi, J.; Cancer Vaccination at Older Age: Gravekamp, C.; Immunology of Aging and Cancer Development: Fulop, T.; Larbi, A.; Kotb, R.; Pawelec, G.; Metabolic Syndrome and Cancer: From Bedside to Bench and Back: Extermann, M.; Frailty: A Common Pathway in Aging and Cancer: Balducci, L.; Targeting Age-Related Changes in the Biology of Acute Myeloid Leukemia: Is the Patient Seeing the Progress?: Vey, N.; Comprehensive Geriatric Assessment in Oncology: Mohile, S.G.; Magnuson, A.; Pharmacology of Aging and Cancer: How Useful Are Pharmacokinetic Tests?: Lichtman, S.M.; Surgery in Older Cancer Patients - Recent Results and New Techniques: Worth the Investment?: van Leeuwen, B.L.; Huisman, M.G.; Audisio, R.A.; Organizing the Geriatrician/Oncologist Partnership: One Size Fits All? Practical Solutions: Holmes, H.M.; Albrand, G.; Geriatric Oncology Nursing: Beyond Standard Care: Overcash, J.; Exercise for Older Cancer Patients: Feasible and Helpful?: Klepin, H.D.; Mohile, S.G.; Mihalko, S.; Aging and Cancer - Addressing a Nation's Challenge: Brechot, J.-M.; Le Quellec-Nathan, M.; Buzyn, A.; Author Index; Subject Index.
