Full Description
Animal models are vital to biomedical research, and they are almost the only way to test basic hypotheses regarding brain formation and function. In this special issue, we have gathered studies addressing how neurodevelopmental adaptations and maladaptations contribute to a wide variety of complex neurological and psychiatric disorders. The papers focus on linking cellular and circuit-level integrative approaches in animal models, including a large number of contributions containing behavioral techniques. Topics covered encompass both genetic and environmental perturbations of mammalian brain development with relevance to the study of attention-deficit hyperactivity disorder, autism, learning disabilities, neurodegeneration, and schizophrenia. Original research in the field is balanced by several focused reviews which summarize current knowledge and identify key gaps in our understanding. The publication provides a valuable source of information by bringing together multiple perspectives for neurologists, psychiatrists, pharmacologist and basic researchers alike.
Contents
Preface: Stanwood, G.D.; Brown, R.W.; Modeling of Autism Genetic Variations in Mice: Focusing on Synaptic and Microcircuit Dysfunctions: Qiu, S.; Aldinger, K.A.; Levitt, P.; The Development and Neurobiology of Infant Attachment and Fear: Landers, M.S.; Sullivan, R.M.; Molecular Substrates of Social Avoidance Seen following Prenatal Ethanol Exposure and Its Reversal by Social Enrichment: Middleton, F.A.; Varlinskaya, E.I.; Mooney, S.M.; The Role of Central Nervous System Development in Late-Onset Neurodegenerative Disorders: Palubinsky, A.M.; Martin, J.A.; McLaughlin, B.A.; Schizophrenia and Substance Abuse Comorbidity: Nicotine Addiction and the Neonatal Quinpirole Model: Brown, R.W.; Maple, A.M.; Perna, M.K.; Sheppard, A.B.; Cope, Z.A.; Kostrzewa, R.M.; Modeling Interneuron Dysfunction in Schizophrenia: Schmidt, M.J.; Mirnics, K.; Preweaning Sensorimotor Deficits and Adolescent Hypersociability in Grin1 Knockdown Mice: Moy, S.S.; Nikolova, V.D.; Riddick, N.V.; Baker, L.K.; Koller, B.H.; Prenatal Cocaine Exposure Decreases Parvalbumin-Immunoreactive Neurons and GABA-to-Projection Neuron Ratio in the Medial Prefrontal Cortex: McCarthy, D.M.; Bhide, P.G.; Brain-Derived Neurotrophic Factor Genotype Impacts the Prenatal Cocaine-Induced Mouse Phenotype: Kabir, Z.D.; Lourenco, F.; Byrne, M.E.; Katzman, A.; Lee, F.; Rajadhyaksha, A.M.; Kosofsky, B.E.; Development and Characterization of NEX-Pten, a Novel Forebrain Excitatory Neuron-Specific Knockout Mouse: Kazdoba, T.M.; Sunnen, C.N.; Crowell, B.; Lee, G.H.; Anderson, A.E.; D'Arcangelo, G.; Depressive-Like Behavior in Adolescents after Maternal Separation: Sex Differences, Controllability, and GABA: Leussis, M.P.; Freund, N.; Brenhouse, H.C.; Thompson, B.S.; Andersen, S.L.; Differential Expression of SLC9A9 and Interacting Molecules in the Hippocampus of Rat Models for Attention Deficit/Hyperactivity Disorder: Zhang-James, Y.; Middleton, F.A.; Sagvolden, T.; Faraone, S.V.; Embryonic Pretreatment with Bromodeoxyuridine Blocks Regeneration and Functional Recovery from Perinatal Medial Frontal Lesions in Rats: Kolb, B.; Pedersen, B.; Gibb, R.; Sensory and Sensorimotor Gating Deficits after Neonatal Ventral Hippocampal Lesions in Rats: Swerdlow, N.R.; Light, G.A.; Breier, M.R.; Shoemaker, J.M.; Saint Marie, R.L.; Neary, A.C.; Geyer, M.A.; Stevens, K.E.; Powell, S.B.; Development of Hyperactivity and Anxiety Responses in Dopamine Transporter-Deficient Mice: Carpenter, A.C.; Saborido, T.P.; Stanwood, G.D.; Sensory and Motor Characterization in the Postnatal Valproate Rat Model of Autism: Reynolds, S.; Millette, A.; Devine, D.P.; Effects of Rat Prenatal Exposure to Valproic Acid on Behaviour and Neuro-Anatomy: Mychasiuk, R.; Richards, S.; Nakahashi, A.; Kolb, B.; Gibb, R.; Changes in Object Recognition and Anxiety-Like Behaviour in Mice Expressing a Cx47 Mutation That Causes Pelizaes-Merzbacher-Like Disease: Zlomuzica, A.; Tress, O.; Binder, S.; Rovira, C.; Willecke, K.; Dere, E.
