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Full Description
In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
Contents
Preface: Filaretova, L.P.; Takeuchi, K.; The 'Gastric Cytoprotection' Concept of Andre Robert and the Origins of a New Series of International Symposia: Szabo, S. et al.; Importance of Translational Research in GI Pharmacology: Lessons Learned from the Successes in History: Chen, D.; Zhao, C.-M.; Acetic Acid Ulcer Model -- State of the Art in 2012: Okabe, S. et al.; Roles of EP4 Receptors in Protective and Healing-Promoting Effects of Prostaglandin E2 on NSAID-Induced Small Intestinal Damage: Takeuchi, K.; Role of Food and Enterobacteria in the Formation and Prevention of Small Intestinal Damage Induced by NSAIDs: Satoh, H.; Takeuchi, K.; Development of NSAIDs with Lower Gastric Side Effect: Mizushima, T.; Animal Model for Evaluating Gastric Bleeding and Ulcerogenic Response Induced by Aspirin plus Clopidogrel: Izuhara, C. et al.; Effects of Ibuprofen, and Some Analogues, on the Muscle Tone of Isolated Segments of the Common Digital Artery of the Fallow Deer (Dama dama): Callingham, B.A. et al.; Psychological Stress Induces Visceral Analgesic or Hyperalgesic Response in Rodents: A Role of Preconditions: Mulak, A. et al.; Neurobiology of Corticotropin-Releasing Factor in the Enteric Nervous System during Stress: Liu, S.; Wood, J.D.; Pathogenic Potential of Psychogenic Stress in Gastric Mucosal Injury: Ovsiannikov, V.I.; Berezina, T.P.; Advances in Understanding Inflammation in Esophageal Disease: Hunt, R.H.; Yuan, Y.; Physiopathology of Esophageal Inflammation, Ulcerogenesis and Repair by Studying the Profile of Glycoconjugate: Zayachkivska, O.; Analysis of the Effect of Different Neuropeptides in Gastric Mucosal Defense Initiated Centrally: Gyires, K.; Sulforaphane Enhances Protection and Repair of Gastric Mucosa against Oxidative Stress via Nrf2-Dependent Mechanisms: Yanaka, A.; Involvement of Renin-Angiotensin System and Vasoactive Angiotensin-(1-7) Metabolite of Angiotensin II in Gastric Mucosal Injury and Gastroprotection: Brzozowski, T. et al.; Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract: Sikiric, P. et al.; Roles of the Hydrogen Sulfide/T-Type Calcium Channel System in Somatic and Visceral Pain Processing: Kawabata, A.; Matsunami, M.; Age-Dependent Role of Vasopressin in Susceptibility of Gastric Mucosa to Indomethacin-Induced Injury: Zelena, D.; Morozova, O.Yu.; Filaretova, L.P.; From Mucosal Energy Metabolism to Capsaicin - Strategies for Understanding Mucosal Protection: Szabo, I.L.; Czimmer, J.; Mozsik, G.
