Advances in Drug Discovery for Alzheimer's Disease (Topics in Medicinal Chemistry)

Wolfe, Michael S (EDT)

Springer, Berlin; Springer（2026/06発売）

• 製本 Hardcover:ハードカバー版
• 商品コード 9783032287298

Full Description

This book reviews recent advances in drug discovery for Alzheimer's disease, focusing on major targets and approaches. Topics include approaches to targeting—directly or indirectly—the two proteins that pathologically accumulate in the brain in Alzheimer's disease, the amyloid β-peptide and the microtubule-associated protein tau, which remain top targets for disease prevention and treatment. A chapter on the emerging area of AI approaches to drug repurposing and discovery will also be included, with examples of the use of big data to identify novel therapeutic modalities. An overview chapter will put these approaches into broader context; describe other important and emerging approaches, targets, and drug candidates; and provide a critical assessment of the potential of these approaches to lead to effective therapeutics. This book is particularly appealing to researchers, clinicians, and students in the fields of medicinal chemistry, neuroscience, pharmacology, and biomedical sciences, as well as anyone interested in the latest advancements in Alzheimer's disease research and drug discovery.

Contents

Drug Discovery for Alzheimer's Disease: Current Status.- Recent Advances in the Development of γ-Secretase Modulators to Treat Alzheimer's Disease.- Beta-Secretase Inhibitors.- Tau Aggregation Inhibitors.- The Role of Molecular Chaperones in Tau Proteostasis: Potential Therapeutic Opportunities in Tauopathies.- Targeting Caspase-2 for the Treatment of Dementia.- The Role of Artificial Intelligence for Drug Repurposing in Alzheimer's Disease.