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Full Description
This textbook covers the foundational principles of biochemistry and molecular biology while also examining how a strong foundation in these disciplines is important for understanding the pathologies of various medical conditions and their connections to drug development. It bridges a gap between traditional biochemistry and molecular cell biology, and their applications to pharmaceutical science, therapies, and clinical practice. The textbook explains how certain pharmaceuticals are designed to target and disrupt basic cellular and biochemical mechanisms. For example, drugs may be designed to interfere with membrane transport proteins, cell signaling pathways, metabolic pathways, or nucleic acid structure and function. This textbook is intended for PharmD students, and students of other medical professions. Each chapter includes self-assessment quizzes, as well as detailed illustrations, diagrams, tables, infographics, and visual aids.
Contents
Section 1: Introduction and basic concepts in cell biology and biochemistry.- Introduction to Biochemistry, Molecular and Cell Biology, and Their Pharmaceutical Applications.- Introduction to Cells in Health and Disease.- Membranes and Membrane Transport in Cell Biology and Drug Action.- Section 2: Basic Protein Structure and Function.- Amino Acids and Protein Structure.- Enzymes, Their Catalytic Properties, and Enzymes as Drug Targets.- Section 3: The Flow of Genetic Information.- DNA and DNA Replication in Normal Cells and Disease.- RNA and Transcription, Abnormalities in Gene Expression in Disease.- Translation, Protein Synthesis, Protein Folding, and Turnover, Pharmacological Interventions That Modulate Protein Turnover.- Section 4: Carbohydrates, lipids, their structure, and metabolism.- Carbohydrates and Lipids.- Carbohydrate Metabolism and Their Role as an Energy Source.- Lipid Metabolism, Lipids in Diet, Health and Disease.- Homeostasis and Regulation of Metabolism in Human Health.- Disorders of Carbohydrate and Lipid Metabolism, and Pharmacological Treatments.- Section 5: Metabolism beyond carbohydrates and lipids.- Amino Acid Metabolism, Related Disorders, and Treatments.- Nucleotide Metabolism and Therapeutic Targets.- One-Carbon Metabolism.- The Role of Vitamins in Human Health and the Effects of Vitamin Deficiencies.- Section 6: Advanced topics.- Signal Transduction and Drugs That Target Signaling Pathways.- Cancer Cells, Oncogenes, and Therapeutic Interventions.- Regulation of the Cell Cycle and Abnormalities in Disease.- Tumor Suppressor Genes and Cancer.- Cell Death and Recycling.- DNA Damage and Repair: Implications for Health and Disease.- Introduction to the Immune System and Virology for Pharmaceutical Sciences.- Section 7: Emerging technologies.- CRISPR and Gene Therapy in Modern Medicine.- Stem Cells and Cellular Therapy.- Introduction to Omics Technologies for Research, Diagnosis, and Drug Discovery.- Drug Delivery and Nanotechnology.- Appendix A: Basic Biochemical Concepts.- Appendix B: Shuttles and Cycles.- Appendix C: Nonstandard Transamination Reactions.
