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Full Description
This book provides a comprehensive overview of non-coding RNAs (ncRNAs), a critical but often overlooked component of our genetic material. It sheds new light on the functional significance of ncRNAs in gene regulation, epigenetic regulation, development and differentiation, cellular processes and disease pathology.
The book follows a logical structure, beginning with chapters introducing ncRNA classifications, biogenesis pathways, regulatory roles and recent advances in functional analysis techniques. The main part discusses their role as therapeutic targets and provides the reader with case studies highlighting the importance of ncRNAs in specific biological processes or diseases. Finally, the book concludes with an outlook on future directions and challenges in ncRNA research.
Because of its scope and thorough introduction, this book is intended not only for researchers in molecular biology, genomics, transcriptomics and epigenetics, but also for students and related disciplines. It provides a holistic understanding of ncRNA biology, their contributions to gene regulation and role in health and disease.
Contents
Chapter 1. Non-coding RNAs: The not so "junk" DNA is the blueprint of the transcriptional landscape of the RNA world.- Chapter 2. Roles of ncRNAs in Neurological Disorders and Cardiovascular Diseases.- Chapter 3. Role of SLC Transporters and Non-coding RNA in Regulating the Genetic Landscape of the Blood Disorders.- Chapter 4. Reconnaissance of The Good, the Bad and the Ugly role of tRNAs in Carcinogenesis and Metastasis.- Chapter 5. The potential of non-coding RNAs -- siRNAs in cancer research and therapy: Challenges and solutions.- Chapter 6. Exploring the Role of Long Non-coding RNAs (lncRNAs) as Biomarkers in Cancers .- Chapter 7. MicroRNAs as Biomarkers for the diagnosis and prognosis of different diseases and cancer.- Chapter 8. The transcriptional role of circular RNAs in drug resistance through miRNAs/mRNAs axis.- Chapter 9. Silhouette of Probiotics in the regulation of miRNAs and lncRNAs in Carcinogenesis and Metastasis: Is it a Silver lining or a Cross to bear.- Chapter 10. Non-coding RNAs in Metabolic Reprogramming of Breast Cancer: Dietary Opportunities and Translational Implications.- Chapter 11. MitomiRs as key players in metabolic reprogramming of blood cell development.- Chapter 12. Non-Coding RNA in Clinical Trials: Diagnostic and Therapeutical Prospects.- Chapter 13. Bioinformatics approaches in non-coding RNAs Research.- Chapter 14. Challenges and perspectives in ncRNA Research.
