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Full Description
This book covers up-to-date knowledge of how designs found in nature use tissue hierarchies to achieve optimal functions, and how these principles are applied in bioengineering. The hierarchy-based multiscale approach has the potential to drive novel biomaterial designs, advance tissue engineering and regeneration, assist in tissue-function integration, improve high-fidelity computational modeling aided by machine learning, and enhance the development of innovative characterization tools and methodologies. This book presents the latest high-impact research achievements in bioengineered and natural hierarchical systems within a clinical context. Our aim is two-fold: (i) to emphasize the importance of integrating and bridging bioengineering designs at various tissue hierarchical levels and (ii) to foster dialogue and collaboration among bioengineers, biomechanists, and clinicians.
Contents
Mechanical and structural contributions of elastin and collagen fibers to interlamellar bonding in the arterial wall.- Tissue engineering of vascular constructs.- Engineering the multiscale complexity of vascular networks.- Epicardial layer and endocardial layer as mechanical protective interfaces for cardiac function.- Dynamic remodeling in live cardiomyocytes.- Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture.- Multiscale light-sheet for rapid assessing of cardiac architecture and function.- Spongiosa as an integrative interface for aortic valve trilayered structure.- Advances in experimental and computational biomechanics of the tricuspid heart valve.- Heterogeneous and multiscale mechanical behavior of aortic valve leaflets.- Multi-scale approach to investigate mechanically-induced changes in tricuspid valve anterior leaflet microstructure.- Multiscale Mechanical Considerations for Polymeric Heart Valve Development.- The stabilization of elastin network in heart valve tissue engineering.- Glutaraldehyde cross-linked mitral valves.- Contribution of glycosaminoglycans to tendon mechanical properties.- Interfibrillar shear stress as the loading mechanism of collagen fibrils in tendon.- Tendon-to-bone Interface: structural-mechanical integration of enthesis.- Hierarchical collagen fiber formation for functional tendon, ligament, and meniscus replacement.- Tissue-engineered collagen graft using a novel load-bearing suture technique.- Tendon/Ligament repair with biomimetic and smart cellular constructs.- Tendon/Ligament-Like tissue via three-dimensional cyclic mechanical stretch culture system.
