Full Description
Bridging neuroscience, immunology, and pharmacology, and bringing together the foremost authorities, Neuroimmune Pharmacology and Therapeutics, 3rd edition, is an invaluable reference and textbook. The text discusses the immunology of the nervous system. New chapters are offered on innate, humoral, and cellular immune responses (innate and adaptive immunity). The additions join each component of the immune response in descriptions for how each affects nervous system function in both health and disease. Next, discussions of neuropharmacology now include both drug development and delivery into brain subregions to optimize clinical responses. This edition features greatly expanded coverage of therapeutics. The new extensions have blossomed into focused therapies engaging the immune system directly, deploying it for drug delivery, attracting the newly evolving field of genetics, vaccinations, and bioengineering, ultimately leading to improved therapeutic disease outcomes. All of the revisions in this edition are designed to bring an early trainee together with a skilled clinical and translational scientist to discuss the state of the art in each part of the emerging field of immunity as it affects the nervous system during steady state and disease and how it can be harnessed for therapeutics and clinical benefit.
Contents
Part I: Immunology of the Nervous System.- Defining Neuroinflammation.- Defining Neuroimmune Pharmacology and Therapeutics .- Immune sensors, Regulators, and Effectors of Brain Health.- B and T Cells.- The Rise of Humanized Mouse Models.- Rise of macaque models for immunity and infection research.- Immunology of the Nervous System Astrocytes, Oligodendrocytes, and Schwann Cells.- Microglial Signaling in Health and Disease.- Mitochondrial Autophagy in Brain.- Neurodevelopment and Drugs.- Autophagic and Lysosomal Disorders.- Cytokines in neurodegenerative disorders.- THE BLOOD-BRAIN BARRIERS.- Neurotransmission of immune cells.- Growth and Neurotrophic Factors for HIV-Associated Neurocognitive Disorders.- Specific Role of Extracellular Vesicles in Controlling Neuroinflammation in Alzheimer's and Parkinson's Disease: Is an EV-based therapy possible?.- Neurotrophins: decades of discoveries.- The Liver-Gut-Brain Axis and Hepatic Encephalopathy.- Hippocampus, Spatial Memory and Neuroimmuomodulation.- The Vertebrate Retina.- Part II: Immunology of Neurodegenerative, Neuroinflammatory, Neuroinfectious and Neuropsychiatric Disorders.- Neurodegeneration.- Alzheimer's Disease.- Parkinson's Disease and Lewy Body Dementias.- Neuropathies.- Neuroimmune dysfunction facilitates COVID-19-associated neurological complications.- Immunopathogenesis of HAM/TSP and Radiological Features of Disease Progression.- Role of Epstein Barr Virus in Multiple Sclerosis.- Virus Induced Encephalitis.- Prion Diseases of Animals and Humans.- Guillain Barrè syndrome and axonal degeneration.- Glaucoma.- Adult Neurogenesis.- Drugs of Abuse.- Part III: Therapies and Diagnostics.- Pharmacogenomics of Neurodegenerative Diseases: Roles in Personalized Medicines.- Immunomodulatory Therapy for Multiple Sclerosis.- Theranostics for Viral Infections.- Advancing Long-Acting Formulations for Treating Chronic Disease.- Ultra long-acting drug delivery formulations.- Therapeutic Strategies in Neurodegenerative Diseases.- Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.- Therapeutic considerations in HIV-associated neurocognitive disorders (HAND).- Control of neuroinflammation and protecting the integrity of the blood-brain barrier.- Proteomics and Genomics in Neuroimmunological Disorders.- Biomarkers for Neurodegenerative Diseases.- Bioimaging of Neuroimmune Disorders: Physical Principles of Neuroimaging Modalities and Clinical Applications.- Bioimaging Biomarkers.- Extracellular Vesicles - Therapeutic Delivery.- Polymeric Nanomaterials for Drug Delivery to the Brain.- Adjuvants for Vaccines.- Immune Transformations for Therapeutic Gain in Neurodegenerative Disease.- Immunotherapy of Alzheimer's Disease.- Immunotherapy for Neurodegenerative Movement Disorders.- Regenerative and Repair Strategies for the Central Nervous System: Progress at the basic and clinical research on Spinal Cord Injury.- Macromolecular Therapeutics - Development and Delivery Engineering.- Therapeutic Gene Editing.- The Neuroimmune System in Psychiatric Disorders.
