Full Description
This is the first book to extensively explore the current state-of-the-art and promise of engram cells, the closest physical approximation of the memory trace to date. Converging evidence suggests that memories are stored, at least in part, as specific populations of engram cells. In this book, the leading experts in engram biology share their continuously refined insights on how engram cells contribute to information encoding and storage, across diverse brain regions and behavioral modalities. "Engrams: A Window into the Memory Trace" is broad in scope and spans molecular, cellular, circuit, computational as well as societal-philosophical aspects of memory engrams. Particular emphasis is placed on their emerging translational value for memory dysfunctions in age and stress-related disorders.
Contents
Section I: Introduction.- Engrams to remember - A conversation between Johannes and Steve.- Section II: Engram cells and their mnemonic role across different brain structures.- Engrams: From behavior to brain-wide networks.- Memory storage in distributed engram cell ensembles.- Hippocampal engrams and contextual memory.- The role of prefrontal ensembles in memory across time - Time-dependent transformations of prefrontal memory ensembles.- Section III: Insights into intra-engram functioning.- All IEGs are not created equal - Molecular sorting within the memory engram.- Unveiling transcriptional and epigenetic mechanisms within engram cells: Insights into memory formation and stability.- The synaptic engram.- Section IV: Beyond associative learning: Engrams for other memory processes.- Engrams of fear memory attenuation.- Adult neurogenesis, context encoding, and pattern separation: A pathway for treating overgeneralization.- What can hippocampal engrams tell us about encoding spatial navigation?.- Understanding others' distress through past experiences: The role of memory engram cells in observational fear.- Section V: Beyond the neurobiology of engrams.- A computational framework for memory engrams.- Engram studies: A call for historical, philosophical and sociological approaches.- If engrams are the answer, what is the question?.
